Journal article
Neurobiology and the Hierarchical Taxonomy of Psychopathology: progress toward ontogenetically informed and clinically useful nosology
Dialogues in clinical neuroscience, Vol.22(1), pp.51-63
03/01/2020
DOI: 10.31887/DCNS.2020.22.1/eperkins
PMCID: 7365294
PMID: 32699505
Abstract
The Hierarchical Taxonomy of Psychopathology (HiTOP) is an empirical structural
model of psychological symptoms formulated to improve the reliability and
validity of clinical assessment. Neurobiology can inform assessments of early
risk and intervention strategies, and the HiTOP model has greater potential to
interface with neurobiological measures than traditional categorical diagnoses
given its enhanced reliability. However, one complication is that observed
biological correlates of clinical symptoms can reflect various factors, ranging
from dispositional risk to consequences of psychopathology. In this paper, we
argue that the HiTOP model provides an optimized framework for conducting
research on the biological correlates of psychopathology from an ontogenetic
perspective that distinguishes among indicators of liability, current symptoms,
and consequences of illness. Through this approach, neurobiological research can
contribute more effectively to identifying individuals at high dispositional
risk, indexing treatment-related gains, and monitoring the consequences of
mental illness, consistent with the aims of the HiTOP framework.
Details
- Title: Subtitle
- Neurobiology and the Hierarchical Taxonomy of Psychopathology: progress toward ontogenetically informed and clinically useful nosology
- Creators
- Emily R. Perkins - Florida State UniversityKeanan J. Joyner - Florida State UniversityChristopher J. Patrick - Florida State UniversityBruce D. Bartholow - University of MissouriRobert D. Latzman - Georgia State UniversityColin G. DeYoung - University of MinnesotaRoman Kotov - Stony Brook UniversityUlrich Reininghaus - Central Institute of Mental HealthSamuel E. Cooper - The University of Texas at AustinMohammad H. Afzali - Université de MontréalAnna R. Docherty - University of UtahMichael N. Dretsch - Walter Reed Army Institute of ResearchNicholas R. Eaton - Stony Brook UniversityVina M. Goghari - University of TorontoJohn D. Haltigan - Centre for Addiction and Mental HealthRobert F. Krueger - University of MinnesotaElizabeth A. Martin - University of California, IrvineGiorgia Michelini - Stony Brook UniversityAnthony C. Ruocco - University of TorontoJennifer L. Tackett - Northwestern UniversityNoah C. Venables - Minneapolis VA Health Care SystemIrwin D. Waldman - Emory UniversityDavid H. Zald - Vanderbilt University
- Resource Type
- Journal article
- Publication Details
- Dialogues in clinical neuroscience, Vol.22(1), pp.51-63
- DOI
- 10.31887/DCNS.2020.22.1/eperkins
- PMID
- 32699505
- PMCID
- 7365294
- NLM abbreviation
- Dialogues Clin Neurosci
- ISSN
- 1294-8322
- eISSN
- 1958-5969
- Publisher
- Les Laboratoires Servier
- Language
- English
- Date published
- 03/01/2020
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984446552102771
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