Journal article
Neurocircuit dynamics of arbitration between decision-making strategies across obsessive-compulsive and related disorders
NeuroImage clinical, Vol.35, pp.103073-103073
01/01/2022
DOI: 10.1016/j.nicl.2022.103073
PMCID: PMC9192960
PMID: 35689978
Abstract
•Obsessive-compulsive and related disorders (OCRD) include OCD and BDD.•Neural differences in decision-making arbitration may underlie OCRD symptoms.•Resting-state effective connectivity was used to assess arbitration circuitry.•Greater left putamen inhibition via left ventrolateral prefrontal cortex in OCRD.•Stronger left putamen inhibition was correlated with less severe symptoms.
Obsessions and compulsions are central components of obsessive–compulsive disorder (OCD) and obsessive–compulsive related disorders such as body dysmorphic disorder (BDD). Compulsive behaviours may result from an imbalance of habitual and goal-directed decision-making strategies. The relationship between these symptoms and the neural circuitry underlying habitual and goal-directed decision-making, and the arbitration between these strategies, remains unknown. This study examined resting state effective connectivity between nodes of these systems in two cohorts with obsessions and compulsions, each compared with their own corresponding healthy controls: OCD (nOCD = 43; nhealthy = 24) and BDD (nBDD = 21; nhealthy = 16). In individuals with OCD, the left ventrolateral prefrontal cortex, a node of the arbitration system, exhibited more inhibitory causal influence over the left posterolateral putamen, a node of the habitual system, compared with controls. Inhibitory causal influence in this connection showed a trend for a similar pattern in individuals with BDD compared with controls. Those with stronger negative connectivity had lower obsession and compulsion severity in both those with OCD and those with BDD. These relationships were not evident within the habitual or goal-directed circuits, nor were they associated with depressive or anxious symptomatology. These results suggest that abnormalities in the arbitration system may represent a shared neural phenotype across these two related disorders that is specific to obsessive–compulsive symptoms. In addition to nosological implications, these results identify potential targets for novel, circuit-specific treatments.
Details
- Title: Subtitle
- Neurocircuit dynamics of arbitration between decision-making strategies across obsessive-compulsive and related disorders
- Creators
- Darsol Seok - University of California, Los AngelesReza Tadayonnejad - University of California, Los AngelesWan-wa Wong - University of California, Los AngelesJoseph O'Neill - Division of Child and Adolescent Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024, USAJeff Cockburn - California Institute of TechnologyAusaf A. Bari - University of California, Los AngelesJohn P. O'Doherty - Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA, 1200 E. California Blvd., Code 228-77, Pasadena, CA 91125, USAJamie D. Feusner - Centre for Addiction and Mental Health
- Resource Type
- Journal article
- Publication Details
- NeuroImage clinical, Vol.35, pp.103073-103073
- DOI
- 10.1016/j.nicl.2022.103073
- PMID
- 35689978
- PMCID
- PMC9192960
- NLM abbreviation
- Neuroimage Clin
- ISSN
- 2213-1582
- eISSN
- 2213-1582
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 01/01/2022
- Academic Unit
- Psychological and Brain Sciences
- Record Identifier
- 9984696653502771
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