Neurocognition and its association with adverse childhood experiences and familial risk of mental illness

Sai Priya Lakkireddy; Srinivas Balachander; Pavithra Dayalamurthy; Mahashweta Bhattacharya; Mino Susan Joseph; Pramod Kumar; Anand Jose Kannampuzha; Sreenivasulu Mallappagari; Shruthi Narayana; Alen Chandy Alexander; Moorthy Muthukumaran; Sweta Sheth; Joan C. Puzhakkal; Vinutha Ramesh; Navya Spurthi Thatikonda; Sowmya Selvaraj; Dhruva Ithal; Vanteemar S. Sreeraj; Jayant Mahadevan; Bharath Holla; Ganesan Venkatasubramanian; John P. John; Pratima Murthy; Vivek Benegal; Y. C. Janardhan Reddy; Sanjeev Jain; A. D. B. S. Consortium; Biju Viswanath; ADBS Consortium

doi:10.1016/j.pnpbp.2022.110620

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Neurocognition and its association with adverse childhood experiences and familial risk of mental illness

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Neurocognition and its association with adverse childhood experiences and familial risk of mental illness

Sai Priya Lakkireddy, Srinivas Balachander, Pavithra Dayalamurthy, Mahashweta Bhattacharya, Mino Susan Joseph, Pramod Kumar, Anand Jose Kannampuzha, Sreenivasulu Mallappagari, Shruthi Narayana, Alen Chandy Alexander, …

Progress in neuro-psychopharmacology & biological psychiatry, Vol.119, pp.110620-110620

12/20/2022

DOI: 10.1016/j.pnpbp.2022.110620

PMCID: PMC7615105

PMID: 35995305

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https://www.ncbi.nlm.nih.gov/pmc/articles/7615105View

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Abstract

Environmental factors such as adverse childhood experiences (ACEs) may affect neurocognition, an endophenotype for several mental illnesses. This study examines the effect of ACEs on neurocognitive performance in first-degree relatives (FDRs) of patients with severe mental illness to determine whether familial risk has a moderating effect on the relationship between ACEs and neurocognition. Unaffected FDRs from multiplex families with severe mental illnesses (schizophrenia, bipolar disorder, obsessive-compulsive disorder, or alcohol use disorder) (n = 324) and healthy controls (with no familial risk) (n = 188) underwent neurocognitive tests for processing speed, new learning, working memory and Theory of Mind. ACEs were measured using the WHO ACEInternational Questionnaire (ACE-IQ). Regression models were done to predict each neurocognitive domain by the effect of familial risk, ACE-IQ Score and their interaction (familial risk*ACE-IQ score). The main effect of familial risk predicted poor performance in all domains of neurocognition (p < 0.01), and the interaction had a negative association with global neurocognition (8 = -0.093, p = 0.009), processing speed (8 = -0.109, p = 0.003) and working memory (8 = -0.092, p = 0.01). Among the ACEs sub-domains, only maltreatment (specifically the main effect of physical neglect and the interaction effect of sexual abuse with familial risk) predicted poorer neurocognition. In FDRs of schizophrenia and bipolar disorder, only the main effects of familial risk were significantly associated with poorer neurocognition. We conclude that there is a relationship between ACEs (especially maltreatment) and neurocognitive functioning, which is moderated by the familial risk of mental illnesses. Genetic/familial vulnerability may have a stronger association with neurocognition in schizophrenia and bipolar disorder.

Clinical Neurology

Life Sciences & Biomedicine

Neurosciences

Neurosciences & Neurology

Pharmacology & Pharmacy

Psychiatry

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Title: Subtitle: Neurocognition and its association with adverse childhood experiences and familial risk of mental illness
Creators: Sai Priya Lakkireddy - National Institute of Mental Health and Neurosciences
Srinivas Balachander - National Institute of Mental Health and Neurosciences
Pavithra Dayalamurthy - National Institute of Mental Health and Neurosciences
Mahashweta Bhattacharya - National Institute of Mental Health and Neurosciences
Mino Susan Joseph - National Institute of Mental Health and Neurosciences
Pramod Kumar - National Institute of Mental Health and Neurosciences
Anand Jose Kannampuzha - National Institute of Mental Health and Neurosciences
Sreenivasulu Mallappagari - National Institute of Mental Health and Neurosciences
Shruthi Narayana - National Institute of Mental Health and Neurosciences
Alen Chandy Alexander - National Institute of Mental Health and Neurosciences
Moorthy Muthukumaran - National Institute of Mental Health and Neurosciences
Sweta Sheth - National Institute of Mental Health and Neurosciences
Joan C. Puzhakkal - National Institute of Mental Health and Neurosciences
Vinutha Ramesh - National Institute of Mental Health and Neurosciences
Navya Spurthi Thatikonda - National Institute of Mental Health and Neurosciences
Sowmya Selvaraj - National Institute of Mental Health and Neurosciences
Dhruva Ithal - National Institute of Mental Health and Neurosciences
Vanteemar S. Sreeraj - National Institute of Mental Health and Neurosciences
Jayant Mahadevan - National Institute of Mental Health and Neurosciences
Bharath Holla - National Institute of Mental Health and Neurosciences
Ganesan Venkatasubramanian - National Institute of Mental Health and Neurosciences
John P. John - National Institute of Mental Health and Neurosciences
Pratima Murthy - National Institute of Mental Health and Neurosciences
Vivek Benegal - National Institute of Mental Health and Neurosciences
Y. C. Janardhan Reddy - National Institute of Mental Health and Neurosciences
Sanjeev Jain - National Institute of Mental Health and Neurosciences
A. D. B. S. Consortium - Natl Inst Mental Hlth & Neurosci, Dept Psychiat, Accelerator Program Discovery Brain Disorders Usin, Bangalore, Karnataka, India
Biju Viswanath - National Institute of Mental Health and Neurosciences
ADBS Consortium
Resource Type: Journal article
Publication Details: Progress in neuro-psychopharmacology & biological psychiatry, Vol.119, pp.110620-110620
DOI: 10.1016/j.pnpbp.2022.110620
PMID: 35995305
PMCID: PMC7615105
NLM abbreviation: Prog Neuropsychopharmacol Biol Psychiatry
ISSN: 0278-5846
eISSN: 1878-4216
Publisher: Elsevier
Number of pages: 10
Grant note: Accelerator Program for Discovery in Brain disorders using Stem cells (ADBS) (by the Depart-ment of Biotechnology, Government of India) BT/PR17316/MED/31/326/2015 / Accelerator Program for Discovery in Brain disorders using Stem cells (ADBS) (Pratiksha trust) IA/CPHI/20/1/505266 / Intermediate (Clinical and Public Health) Fellowship of the DBT/Wellcome Trust India Alliance; Wellcome Trust
Language: English
Date published: 12/20/2022
Academic Unit: Psychiatry
Record Identifier: 9984843606202771

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