Journal article
Neurocognitive profiles of preterm infants randomly assigned to lower or higher hematocrit thresholds for transfusion
Child neuropsychology, Vol.17(4), pp.347-367
07/01/2011
DOI: 10.1080/09297049.2010.544647
PMCID: PMC3115491
PMID: 21360360
Abstract
Objective: Preterm infants are frequently transfused with red blood cells based on standardized guidelines or clinical concerns that anemia taxes infants' physiological compensatory mechanisms and thereby threatens their health and well-being. The impact of various transfusion guidelines on long-term neurocognitive outcome is not known. The purpose of this study is to evaluate long-term neurocognitive outcome on children born prematurely and treated at birth with different transfusion guidelines.
Methods: Neurocognitive outcomes were examined at school age for 56 preterm infants randomly assigned to a liberal (n = 33) or restrictive (n = 23) transfusion strategy. Tests of intelligence, achievement, language, visual-spatial/motor, and memory skills were administered. Between-group differences were assessed.
Results: Those in the liberal transfusion group performed more poorly than those in the restrictive group on measures of associative verbal fluency, visual memory, and reading.
Conclusions: Findings highlight possible long-term neurodevelopmental consequences of maintaining higher hematocrit levels.
Details
- Title: Subtitle
- Neurocognitive profiles of preterm infants randomly assigned to lower or higher hematocrit thresholds for transfusion
- Creators
- Thomasin E McCoy - Department of Pediatrics , University of IowaAmy L Conrad - Department of Psychiatry Research , The University of Iowa Hospitals and ClinicsLynn C Richman - Department of Pediatrics , University of IowaScott D Lindgren - Department of Pediatrics , University of IowaPeg C Nopoulos - Department of Psychiatry , University of IowaEdward F Bell - Department of Pediatrics , University of Iowa
- Resource Type
- Journal article
- Publication Details
- Child neuropsychology, Vol.17(4), pp.347-367
- DOI
- 10.1080/09297049.2010.544647
- PMID
- 21360360
- PMCID
- PMC3115491
- NLM abbreviation
- Child Neuropsychol
- ISSN
- 0929-7049
- eISSN
- 1744-4136
- Publisher
- Taylor & Francis Group
- Language
- English
- Date published
- 07/01/2011
- Academic Unit
- Neurology; Psychiatry; Pediatric Psychology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Craniofacial Anomalies Research Center; Neonatology
- Record Identifier
- 9984003992802771
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