Neurocognitive sequelae in African American and Caucasian children with multiple sclerosis

K A Ross; D C Schwebel; J Rinker II; J Ness; J Ackerson

doi:10.1212/WNL.0b013e318200d7b9

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Neurocognitive sequelae in African American and Caucasian children with multiple sclerosis

Journal article

Peer reviewed

Neurocognitive sequelae in African American and Caucasian children with multiple sclerosis

K A Ross, D C Schwebel, J Rinker II, J Ness and J Ackerson

Neurology, Vol.75(23), pp.2097-2102

12/07/2010

DOI: 10.1212/WNL.0b013e318200d7b9

PMCID: PMC3385422

PMID: 21135383

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Abstract

To examine domain-specific neurocognitive differences between African American (AA) and Caucasian (CA) patients with pediatric-onset multiple sclerosis (POMS). An extensive battery of neuropsychological tests was given to each subject, including tests in all major domains of cognitive function. Point-biserial correlations between ethnicity and test performance were computed. Significant correlations were followed up with hierarchical multiple regression analysis, accounting for clinical and demographic variables before examining ethnic differences. Forty-two patients with POMS including 20 AA and 22 CA subjects were assessed. The cohorts did not differ in age, gender, socioeconomic status, disease duration, disability score, immunoglobulin G index, or number of relapses in the first 2 years of disease. Retaining some of these variables as covariates in the hierarchical regression analysis, the AA cohort performed worse on measures of language (p < 0.001) and complex attention (p < 0.01) than their CA peers. AA patients with POMS may be at higher risk for adverse cognitive impact in the areas of language and complex attention. Longitudinal characterization of cognitive pathology is critical for the development of effective intervention strategies to prolong cognitive functioning in POMS cohorts.

Adolescent

Black or African American

Child

Cognition Disorders - ethnology

Cognition Disorders - etiology

Female

Humans

Immunoglobulin G - blood

Male

Multiple Sclerosis - complications

Multiple Sclerosis - ethnology

Neuropsychological Tests

Regression Analysis

White People

Young Adult

Details

Title: Subtitle: Neurocognitive sequelae in African American and Caucasian children with multiple sclerosis
Creators: K A Ross - University of Alabama at Birmingham
D C Schwebel - University of Alabama at Birmingham
J Rinker II - University of Alabama at Birmingham
J Ness - University of Alabama at Birmingham
J Ackerson - St. Vincent's Birmingham
Resource Type: Journal article
Publication Details: Neurology, Vol.75(23), pp.2097-2102
DOI: 10.1212/WNL.0b013e318200d7b9
PMID: 21135383
PMCID: PMC3385422
NLM abbreviation: Neurology
ISSN: 0028-3878
eISSN: 1526-632X
Grant note: 3R01HD058573-01A1S1 / NICHD NIH HHS CCU409679 / PHS HHS 5R01HD058573-02 / NICHD NIH HHS K08NS43220 / NINDS NIH HHS 5R01HD30149-11 / NICHD NIH HHS
Language: English
Date published: 12/07/2010
Academic Unit: Research Administration
Record Identifier: 9984949200802771

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