Journal article
Neurodevelopmental Outcomes in Postnatal Growth-Restricted Preterm Infants with Postnatal Head-Sparing
Journal of perinatology, Vol.36(12), pp.1116-1121
09/15/2016
DOI: 10.1038/jp.2016.154
PMCID: PMC5130598
PMID: 27629374
Abstract
Objective:To compare neurodevelopmental outcomes in postnatal growth-restricted infants born <29 weeks with and without postnatal head-sparing (PHS).Study Design:We analyzed developmental outcomes at 2 years of age among postnatally growth-restricted infants with and without head-sparing. The primary outcome was Bayley III cognitive composite score; secondary outcomes included Bayley III motor composite score, moderate/severe cerebral palsy, gross motor functional classification scale level≥2, and presence or absence of neurodevelopmental impairment (NDI).Results:Of 1098 infants evaluated at 18 to 22 months, 658 were postnatally growth restricted, of whom 301 had head-sparing. In the multivariate model including independent risk factors for poor growth and poor developmental outcome, infants with head-sparing had higher adjusted motor composite scores (mean difference 4.65, P<0.01), but no differences in other neurodevelopmental outcomes.Conclusion:PHS is associated with improved neurodevelopmental outcome in extremely preterm infants, specifically Bayley III motor scores, but whether beneficial effects of PHS persist later in life is unknown.
Details
- Title: Subtitle
- Neurodevelopmental Outcomes in Postnatal Growth-Restricted Preterm Infants with Postnatal Head-Sparing
- Creators
- Jeffrey M. Meyers - University of RochesterCarla M. Bann - RTI InternationalBarbara J. Stoll - Children's Healthcare of AtlantaCarl T. D’Angio - Department of Pediatrics, University of Rochester School of Medicine and Dentistry Social, Statistical and Environmental Sciences Unit, RTI International Department of Pediatrics, Emory University School of Medicine and Children’s Healthcare of Atlanta Department of Pediatrics, University of Iowa Department of Pediatrics, University of Texas Medical School at HoustonEdward F. Bell - University of IowaAndrea F. Duncan - Department of Pediatrics, University of Texas Medical School at Houston, Houston, TX, USARonnie Guillet - University of RochesterEunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
- Resource Type
- Journal article
- Publication Details
- Journal of perinatology, Vol.36(12), pp.1116-1121
- DOI
- 10.1038/jp.2016.154
- PMID
- 27629374
- PMCID
- PMC5130598
- ISSN
- 0743-8346
- eISSN
- 1476-5543
- Language
- English
- Date published
- 09/15/2016
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984353929602771
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