Journal article
Neurodevelopmental Outcomes of Prenatal Preeclampsia Exposure
Trends in neurosciences (Regular ed.), Vol.43(4), pp.253-268
04/2020
DOI: 10.1016/j.tins.2020.02.003
PMID: 32209456
Abstract
Preeclampsia is a dangerous hypertensive disorder of pregnancy with known links to negative child health outcomes. Here, we review epidemiological and basic neuroscience work from the past several decades linking prenatal preeclampsia to altered neurodevelopment. This work demonstrates increased rates of neuropsychiatric disorders [e.g., increased autism spectrum disorder, attention deficit hyperactivity disorder (ADHD)] in children of preeclamptic pregnancies, as well as increased rates of cognitive impairments [e.g., decreased intelligence quotient (IQ), academic performance] and neurological disease (e.g., stroke and epilepsy). We also review findings from multiple animal models of preeclampsia. Manipulation of key clinical preeclampsia processes in these models (e.g., placental hypoxia, immune dysfunction, angiogenesis, oxidative stress) causes various disruptions in offspring, including ones in white matter/glia, glucocorticoid receptors, neuroimmune outcomes, cerebrovascular structure, and cognition/behavior. This animal work implicates potentially high-yield targets that may be leveraged in the future for clinical application.
Preeclampsia exposure in utero increases later risk for psychiatric and neurological problems and is associated with brain morphological, white matter, and vascular abnormalities.Neurodevelopmental processes are likely affected by dysregulation of immune, oxidative stress, growth factor, and angiogenic processes in maternal, placental, and fetal physiology during preeclampsia.Animal models have highlighted multiple mechanisms underlying this risk and potential therapeutic/intervention targets.
Details
- Title: Subtitle
- Neurodevelopmental Outcomes of Prenatal Preeclampsia Exposure
- Creators
- Serena B Gumusoglu - Department of Psychiatry, University of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, IA, USAAkanksha S.S Chilukuri - Department of Psychiatry, University of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, IA, USADonna A Santillan - University of Iowa Carver College of Medicine, Department of Obstetrics and Gynecology, Iowa City, IA, USAMark K Santillan - University of Iowa Carver College of Medicine, Department of Obstetrics and Gynecology, Iowa City, IA, USAHanna E Stevens - Department of Psychiatry, University of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Trends in neurosciences (Regular ed.), Vol.43(4), pp.253-268
- DOI
- 10.1016/j.tins.2020.02.003
- PMID
- 32209456
- NLM abbreviation
- Trends Neurosci
- ISSN
- 0166-2236
- eISSN
- 1878-108X
- Publisher
- Elsevier Ltd
- Grant note
- name: NIH; DOI: 10.13039/100000968, name: American Heart Association
- Language
- English
- Date published
- 04/2020
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Obstetrics and Gynecology
- Record Identifier
- 9984070345702771
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