Journal article
Neurodevelopmental Outcomes of Triplets or Higher-Order Extremely Low Birth Weight Infants
Pediatrics (Evanston), Vol.127(3), pp.e654-e660
03/2011
DOI: 10.1542/peds.2010-2646
PMCID: PMC3304548
PMID: 21357334
Abstract
BACKGROUND: Extremely low birth weight twins have a higher rate of death or neurodevelopmental impairment than singletons. Higher-order extremely low birth weight multiple births may have an even higher rate of death or neurodevelopmental impairment.
METHODS: Extremely low birth weight (birth weight 401–1000 g) multiple births born in participating centers of the Neonatal Research Network between 1996 and 2005 were assessed for death or neurodevelopmental impairment at 18 to 22 months' corrected age. Neurodevelopmental impairment was defined by the presence of 1 or more of the following: moderate to severe cerebral palsy; mental developmental index score or psychomotor developmental index score less than 70; severe bilateral deafness; or blindness. Infants who died within 12 hours of birth were excluded. Maternal and infant demographic and clinical variables were compared among singleton, twin, and triplet or higher-order infants. Logistic regression analysis was performed to establish the association between singletons, twins, and triplet or higher-order multiples and death or neurodevelopmental impairment, controlling for confounding variables that may affect death or neurodevelopmental impairment.
RESULTS: Our cohort consisted of 8296 singleton, 2164 twin, and 521 triplet or higher-order infants. The risk of death or neurodevelopmental impairment was increased in triplets or higher-order multiples when compared with singletons (adjusted odds ratio: 1.7 [95% confidence interval: 1.29–2.24]), and there was a trend toward an increased risk when compared with twins (adjusted odds ratio: 1.27 [95% confidence: 0.95–1.71]).
CONCLUSIONS: Triplet or higher-order births are associated with an increased risk of death or neurodevelopmental impairment at 18 to 22 months' corrected age when compared with extremely low birth weight singleton infants, and there was a trend toward an increased risk when compared with twins.
Details
- Title: Subtitle
- Neurodevelopmental Outcomes of Triplets or Higher-Order Extremely Low Birth Weight Infants
- Creators
- Rajan Wadhawan - West Coast Neonatology, All Children's Hospital, St Petersburg, FloridaEdward F Bell - Department of Pediatrics, University of Iowa, Iowa City, IowaWilliam Oh - Department of Pediatrics, Women & Infants Hospital, Providence, Rhode IslandBetty R Vohr - Department of Pediatrics, Women & Infants Hospital, Providence, Rhode IslandLisa Wrage - Statistics and Epidemiology Unit, Research Triangle Institute International, Research Triangle Park, North CarolinaAbhik Das - Statistics and Epidemiology Unit, Research Triangle Institute International, Rockville, MarylandAbbot R Laptook - Department of Pediatrics, Women & Infants Hospital, Providence, Rhode IslandSeetha Shankaran - Department of Pediatrics, Wayne State University, Detroit, MichiganBarbara J Stoll - Department of Pediatrics, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GeorgiaMichele C Walsh - Department of Pediatrics, Rainbow Babies & Children's Hospital, Case Western Reserve University, Cleveland, Ohio; andRosemary D Higgins - Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MarylandEunice Kennedy Shriver National Institute of Child Health & Human Development Neonatal Research Network
- Resource Type
- Journal article
- Publication Details
- Pediatrics (Evanston), Vol.127(3), pp.e654-e660
- DOI
- 10.1542/peds.2010-2646
- PMID
- 21357334
- PMCID
- PMC3304548
- NLM abbreviation
- Pediatrics
- ISSN
- 0031-4005
- eISSN
- 1098-4275
- Publisher
- American Academy of Pediatrics
- Language
- English
- Date published
- 03/2011
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984093481602771
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