Journal article
Neurodevelopmental and Behavioral Outcomes in Extremely Premature Neonates With Ventriculomegaly in the Absence of Periventricular-Intraventricular Hemorrhage
JAMA pediatrics, Vol.172(1), pp.32-42
01/01/2018
DOI: 10.1001/jamapediatrics.2017.3545
PMCID: PMC5833521
PMID: 29181530
Abstract
Studies of cranial ultrasonography and early childhood outcomes among cohorts of extremely preterm neonates have linked periventricular-intraventricular hemorrhage and cystic periventricular leukomalacia with adverse neurodevelopmental outcomes. However, the association between nonhemorrhagic ventriculomegaly and neurodevelopmental and behavioral outcomes is not fully understood.
To characterize the outcomes of extremely preterm neonates younger than 27 weeks' gestational age who experienced nonhemorrhagic ventriculomegaly that was detected prior to 36 weeks' postmenstrual age.
This longitudinal observational study was conducted at 16 centers of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Infants born prior to 27 weeks' gestational age in any network facility between July 1, 2006, and June 30, 2011, were included if they had a cranial ultrasonogram performed prior to 36 weeks' postmenstrual age. Comparisons were made between those with ventriculomegaly and those with normal cranial sonograms. Data analysis was completed from August 2013 to August 2017.
The main outcome was neurodevelopmental impairment, defined as a Bayley Scales of Infant and Toddler Development III cognitive score less than 70, moderate/severe cerebral palsy, a Gross Motor Function Classification System score of level 2 or more, vision impairment, or hearing impairment. Secondary outcomes included Bayley Scales of Infant and Toddler Development III subscores, components of neurodevelopmental impairment, behavioral outcomes, and death/neurodevelopmental impairment. Logistic regression was used to evaluate the association of ventriculomegaly with adverse outcomes while controlling for potentially confounding variables and center differences as a random effect. Linear regression was used similarly for continuous outcomes.
Of 4193 neonates with ultrasonography data, 300 had nonhemorrhagic ventriculomegaly (7%); 3045 had normal cranial ultrasonograms (73%), 775 had periventricular-intraventricular hemorrhage (18.5%), and 73 had cystic periventricular leukomalacia (1.7%). Outcomes were available for 3008 of 3345 neonates with ventriculomegaly or normal scans (90%). Compared with normal cranial ultrasonograms, ventriculomegaly was associated with lower gestational age, male sex, and bronchopulmonary dysplasia, late-onset sepsis, meningitis, necrotizing enterocolitis, and stage 3 retinopathy of prematurity. After adjustment, neonates with ventriculomegaly had higher odds of neurodevelopmental impairment (odds ratio [OR], 3.07; 95% CI, 2.13-4.43), cognitive impairment (OR, 3.23; 95% CI, 2.09-4.99), moderate/severe cerebral palsy (OR, 3.68; 95% CI, 2.08-6.51), death/neurodevelopmental impairment (OR, 2.17; 95% CI, 1.62-2.91), but not death alone (OR, 1.09; 95% CI, 0.76-1.57). Behavioral outcomes did not differ.
Nonhemorrhagic ventriculomegaly is associated with increased odds of neurodevelopmental impairment among extremely preterm neonates.
Details
- Title: Subtitle
- Neurodevelopmental and Behavioral Outcomes in Extremely Premature Neonates With Ventriculomegaly in the Absence of Periventricular-Intraventricular Hemorrhage
- Creators
- Athina Pappas - Wayne State UniversityIra Adams-Chapman - Emory UniversitySeetha Shankaran - Wayne State UniversityScott A McDonald - Environmental Protection AgencyBarbara J Stoll - The University of Texas Health Science Center at HoustonAbbot R Laptook - Brown UniversityWaldemar A Carlo - University of AlabamaKrisa P Van Meurs - Stanford UniversitySusan R Hintz - Stanford UniversityMartha D Carlson - University of Michigan–Ann ArborJane E Brumbaugh - University of IowaMichele C Walsh - Case Western Reserve UniversityMyra H Wyckoff - The University of Texas Southwestern Medical CenterAbhik Das - RTI InternationalRosemary D Higgins - National Institutes of HealthEunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
- Contributors
- Tarah T Colaizy (Contributor) - University of Iowa, NeonatologyEdward F Bell (Contributor) - University of Iowa, Neonatology
- Resource Type
- Journal article
- Publication Details
- JAMA pediatrics, Vol.172(1), pp.32-42
- DOI
- 10.1001/jamapediatrics.2017.3545
- PMID
- 29181530
- PMCID
- PMC5833521
- ISSN
- 2168-6203
- eISSN
- 2168-6211
- Grant note
- UG1 HD021385 / NICHD NIH HHS UG1 HD040689 / NICHD NIH HHS UG1 HD087226 / NICHD NIH HHS UG1 HD027904 / NICHD NIH HHS UG1 HD021364 / NICHD NIH HHS UG1 HD027853 / NICHD NIH HHS UG1 HD027880 / NICHD NIH HHS
- Language
- English
- Date published
- 01/01/2018
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984354119502771
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