Journal article
Neurodevelopmental outcome at 2 years of age after general anaesthesia and awake-regional anaesthesia in infancy (GAS): an international multicentre, randomised controlled trial
The Lancet (British edition), Vol.387(10015), pp.239-250
01/16/2016
DOI: 10.1016/S0140-6736(15)00608-X
PMCID: PMC5023520
PMID: 26507180
Abstract
Preclinical data suggest that general anaesthetics affect brain development. There is mixed evidence from cohort studies that young children exposed to anaesthesia can have an increased risk of poor neurodevelopmental outcome. We aimed to establish whether general anaesthesia in infancy has any effect on neurodevelopmental outcome. Here we report the secondary outcome of neurodevelopmental outcome at 2 years of age in the General Anaesthesia compared to Spinal anaesthesia (GAS) trial.
Details
- Title: Subtitle
- Neurodevelopmental outcome at 2 years of age after general anaesthesia and awake-regional anaesthesia in infancy (GAS): an international multicentre, randomised controlled trial
- Creators
- Andrew J Davidson - Anaesthesia and Pain Management Research Group, Murdoch Childrens Research Institute, Melbourne, VIC, Australia; Melbourne Children's Trials Centre, Murdoch Childrens Research Institute, Melbourne, VIC, Australia; Department of Anaesthesia and Pain Management, The Royal Children's Hospital, Melbourne, VIC, Australia; Department of Paediatrics, University of Melbourne, Melbourne, VIC, Australia. Electronic address: andrew.davidson@rch.org.auNicola Disma - Department of Anesthesia, Istituto Giannina Gaslini, Genoa, ItalyJurgen C de Graaff - Department of Anaesthesia, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, NetherlandsDavinia E Withington - Department of Anesthesia, Montreal Children's Hospital, Montreal, Canada; Department of Anesthesia, McGill University, Montreal, CanadaLiam Dorris - Mental Health and Wellbeing, University of Glasgow, Glasgow, UKGraham Bell - Department of Anaesthesia, Royal Hospital for Children, Glasgow, UKRobyn Stargatt - School of Psychological Science, La Trobe University, Victoria, VIC, Australia; Child Neuropsychology, Murdoch Childrens Research Institute, Melbourne, VIC, AustraliaDavid C Bellinger - Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Department of Psychiatry, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Department of Environmental Health, Harvard T H Chan School of Public Health, Boston, MA, USATibor Schuster - Clinical Epidemiology and Biostatistics Unit, Murdoch Childrens Research Institute, Melbourne, VIC, AustraliaSarah J Arnup - Clinical Epidemiology and Biostatistics Unit, Murdoch Childrens Research Institute, Melbourne, VIC, AustraliaPollyanna Hardy - National Perinatal Epidemiology Unit, Clinical Trials Unit, University of Oxford, Oxford, UKRodney W Hunt - Department of Paediatrics, University of Melbourne, Melbourne, VIC, Australia; Neonatal Research Group, Murdoch Childrens Research Institute, Melbourne, VIC, Australia; Department of Neonatal Medicine, The Royal Children's Hospital, Melbourne, AustraliaMichael J Takagi - Anaesthesia and Pain Management Research Group, Murdoch Childrens Research Institute, Melbourne, VIC, Australia; Child Neuropsychology, Murdoch Childrens Research Institute, Melbourne, VIC, AustraliaGaia Giribaldi - Department of Anesthesia, Istituto Giannina Gaslini, Genoa, ItalyPenelope L Hartmann - Anaesthesia and Pain Management Research Group, Murdoch Childrens Research Institute, Melbourne, VIC, AustraliaIda Salvo - Department of Anesthesiology and Pediatric Intensive Care, Ospedale Pediatrico 'Vittore Buzzi', Milan, ItalyNeil S Morton - Department of Anaesthesia, Royal Hospital for Children, Glasgow, UK; University of Glasgow, Glasgow, UKBritta S von Ungern Sternberg - School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia; Department of Anaesthesia and Pain Management, Princess Margaret Hospital for Children, Perth, WA, AustraliaBruno Guido Locatelli - Department of Anesthesia, Ospedale Papa Giovanni XXIII, Bergamo, ItalyNiall Wilton - Department of Paediatric Anaesthesia and Operating Rooms, Starship Children's Hospital, Auckland District Health Board, Auckland, New ZealandAnne Lynn - Department of Anesthesiology, University of Washington, Seattle, WA, USAJoss J Thomas - Department of Anesthesia, University of Minnesota, Minneapolis, MN, USADavid Polaner - Department of Anesthesiology, Children's Hospital Colorado and University of Colorado School of Medicine, Aurora, CO, USAOliver Bagshaw - Department of Anaesthesia, Birmingham Children's Hospital, Birmingham, UKPeter Szmuk - Department of Anesthesiology, Children's Medical Centre Dallas, Dallas, TX, USAAnthony R Absalom - Department of Anaesthesiology, University Medical Centre Groningen, Groningen University, Groningen, NetherlandsGeoff Frawley - Anaesthesia and Pain Management Research Group, Murdoch Childrens Research Institute, Melbourne, VIC, Australia; Department of Anaesthesia and Pain Management, The Royal Children's Hospital, Melbourne, VIC, AustraliaCharles Berde - Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USAGillian D Ormond - Anaesthesia and Pain Management Research Group, Murdoch Childrens Research Institute, Melbourne, VIC, AustraliaJacki Marmor - Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USAMary Ellen McCann - Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USAGAS consortium
- Contributors
- Denisa M Haret (Contributor) - University of Iowa, Anesthesia
- Resource Type
- Journal article
- Publication Details
- The Lancet (British edition), Vol.387(10015), pp.239-250
- Publisher
- England
- DOI
- 10.1016/S0140-6736(15)00608-X
- PMID
- 26507180
- PMCID
- PMC5023520
- ISSN
- 0140-6736
- eISSN
- 1474-547X
- Grant note
- R01 HD061336 / NICHD NIH HHS R01 HD084566 / NICHD NIH HHS 07/01/05 / Department of Health FDA-SOL-08-SAFEKIDS-CLIN 002-PROJECT / PHS HHS MCT-98031 / CIHR U54 HD090255 / NICHD NIH HHS 1-R01 HD06 1136-01A1 / NICHD NIH HHS
- Language
- English
- Date published
- 01/16/2016
- Academic Unit
- Anesthesia
- Record Identifier
- 9984007158002771
Metrics
19 Record Views