Journal article
Neurodevelopmental outcomes in a cohort of children with congenital Zika syndrome at 12 and 24 months of age
Child : care, health & development, Vol.49(2), pp.304-310
03/2023
DOI: 10.1111/cch.13044
PMID: 35959569
Abstract
Background
Early child development is a critical stage of life that influences social, educational and health outcomes worldwide. A few years after Zika epidemic, families of children born with congenital Zika syndrome (CZS) continue to face uncertainties when it comes to the development of their children. The present study sought to analyse the developmental trajectories of a subset of children born with CZS in the first 24 months of life.
Methods
Thirty-five children with CZS were assessed with the Bayley-III Scales at 12 and 24 months of age from November 2016 to December 2018 in a rehabilitation centre in Brazil. Inclusion criteria included children with established diagnosis of CZS. Exclusion criteria included the presence of arthrogryposis, prematurity, irregular follow-up, clinical complications or other causes of microcephaly. Children born with CZS who evolved with cerebral palsy (CP) were classified according to the Gross Motor Function Classification System (GMFCS) at 2 years of age.
Results
At 12 months of age mean composite scores on the Bayley cognitive, communication and motor scores were 57.71 (SD 7.11), 57.94 (SD 14.34) and 49.26 (7.20), respectively. At 24 months of age, composite scores were 57.43 (SD 7.11), 53.60 (SD 12.29) and 48.83 (7.76). In addition, 31 (88.57%) out of 34 children diagnosed with CP were classified as GMFCS levels IV and V.
Conclusion
Zika virus congenital infection is a risk factor for functional impairments across all developmental domains having a direct and substantial negative impact in early child development.
Details
- Title: Subtitle
- Neurodevelopmental outcomes in a cohort of children with congenital Zika syndrome at 12 and 24 months of age
- Creators
- Fernanda J. P. Marques - Universidade Federal FluminenseClaret Amarante - Sarah Network of Rehabilitation HospitalsMarco Aurelio C. Elias - Sarah Network of Rehabilitation HospitalsRenata Klein - Sarah Network of Rehabilitation HospitalsOsvaldo J. M. Nascimento - Universidade Federal FluminenseMarcio Leyser - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Child : care, health & development, Vol.49(2), pp.304-310
- DOI
- 10.1111/cch.13044
- PMID
- 35959569
- ISSN
- 0305-1862
- eISSN
- 1365-2214
- Language
- English
- Electronic publication date
- 08/18/2022
- Date published
- 03/2023
- Academic Unit
- Stead Family Department of Pediatrics; Developmental and Behavioral Pediatrics
- Record Identifier
- 9984353943302771
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