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Neurodevelopmental outcomes relevant to autism in juvenile mice exposed to PCB 11 in the maternal diet throughout gestation and lactation
Journal article   Open access   Peer reviewed

Neurodevelopmental outcomes relevant to autism in juvenile mice exposed to PCB 11 in the maternal diet throughout gestation and lactation

Rebecca J. Wilson, Harmanpreet K. Panesar, Ilknur Dursun, Rosalia Mendieta, Peter M. Andrew, Xueshu Li, Hans-Joachim Lehmler and Pamela J. Lein
Frontiers in toxicology, Vol.8, 1816944
08/12/2026
DOI: 10.3389/ftox.2026.1816944
url
https://doi.org/10.3389/ftox.2026.1816944View
Published (Version of record) Open Access

Abstract

Polychlorinated biphenyls (PCBs) pose a significant risk to the developing human brain, and recent epidemiological data suggest PCBs increase the risk and/or severity of neurodevelopmental disorders (NDD), including autism spectrum disorder (autism). Experimental animal studies confirm that PCBs disrupt neurodevelopment, resulting in behavioral deficits. Historically, research on the developmental neurotoxicity of PCBs has focused on the higher-chlorinated PCBs found in legacy commercial mixtures; however, lower-chlorinated PCBs (LC-PCBs), including congeners not present in commercial mixtures, predominate in contemporary human exposures. Previous in vitro studies demonstrated that one such LC-PCB, PCB 11, altered dendritic arborization, a cellular phenotype common to multiple NDD. Whether PCB 11 modulates dendritic morphogenesis in vivo is not known. In this study, we investigated how gestational and lactational exposure to PCB 11 in the maternal diet affected critical neurodevelopmental processes in juvenile male and female mice. C57BL/6J mouse dams were exposed to vehicle or PCB 11 at 0.1 or 1.0 mg/kg/day in their diet for 2 weeks prior to mating and throughout gestation and lactation. Brain tissue was collected from offspring at postnatal day (P)4 and P21 to assess dendritic arborization, apoptosis, glial reactivity, and neurogenesis in the hippocampus and neocortex. PCB 11 dose-dependently reduced the dendritic arborization of pyramidal neurons in the neocortex by 13%–25% but had no significant effect on the dendritic morphogenesis of pyramidal neurons in the hippocampus. Apoptosis was not altered by PCB 11 in either brain region of either sex at either age. While PCB 11 had no effect on neurogenesis at P4, it dose-dependently decreased neurogenesis by 15%–70% in the dentate gyrus at P21. GFAP immunoreactivity and the morphological complexity of astrocytes were increased by 40%–60% and 20%–60%, respectively, in the CA1 hippocampus of female mice exposed to 0.1 mg/kg/day PCB 11; in contrast, PCB 11 had no effect on IBA1 immunoreactivity. These findings demonstrate that developmental exposure to PCB 11 promoted NDD-relevant cellular phenotypes in a dose, sex, and region-dependent manner, providing experimental evidence in support of epidemiological data identifying PCBs as potential NDD risk modifiers. Ongoing studies are investigating behavioral responses in weanling mice developmentally exposed to PCB 11.
apoptosis dendritic arborization developmental neurotoxicity glial reactivity neurodevelopmental disorders neurogenesis polychlorinated biphenyls

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