Neurodevelopmental vulnerability of the corpus callosum to childhood onset localization-related epilepsy

Bruce Hermann; Russ Hansen; Michael Seidenberg; Vince Magnotta; Dan O'Leary

doi:10.1016/S1053-8119(02)00044-7

Back

Neurodevelopmental vulnerability of the corpus callosum to childhood onset localization-related epilepsy

Journal article

Peer reviewed

Neurodevelopmental vulnerability of the corpus callosum to childhood onset localization-related epilepsy

Bruce Hermann, Russ Hansen, Michael Seidenberg, Vince Magnotta and Dan O'Leary

NeuroImage (Orlando, Fla.), Vol.18(2), pp.284-292

02/2003

DOI: 10.1016/S1053-8119(02)00044-7

PMID: 12595183

View Online

Abstract

Recent research has suggested that childhood onset of localization-related (focal) temporal lobe epilepsy is associated with a generalized adverse effect on cognition and brain structure, especially cerebral white matter volume. This study examined the neurodevelopmental impact of childhood onset epilepsy on corpus callosum volume and the cognitive consequences of reduced cerebral connectivity. Healthy controls (n = 15) and patients with temporal lobe epilepsy (n = 32) were matched on gender and handedness, and childhood and adult onset epilepsy groups were matched on duration of epilepsy (mean = 19 years) but varied in neurodevelopmental age at onset of recurrent seizures. Results showed that childhood onset of temporal lobe epilepsy was associated with significant volumetric reduction of the corpus callosum compared to both late onset and healthy controls, with the latter two groups not differing from one another. The volumetric loss was most evident in posterior followed by anterior corpus callosum. Volumetric reduction of the corpus callosum in temporal lobe epilepsy was of clinical significance with smaller volumes associated with poorer performance on measures of nonverbal problem solving, immediate memory, speeded complex psychomotor ability and fine motor dexterity. These findings indicate that childhood onset of temporal lobe epilepsy is associated with an adverse neurodevelopmental impact on brain connectivity which is of clinical consequence and theoretical interest.

Corpus Callosum - physiopathology

Humans

Middle Aged

Risk Factors

Cerebral Cortex - pathology

Image Interpretation, Computer-Assisted

Epilepsy, Temporal Lobe - physiopathology

Male

Reference Values

Brain Damage, Chronic - physiopathology

Cerebral Cortex - physiopathology

Neuropsychological Tests

Magnetic Resonance Imaging

Corpus Callosum - pathology

Adolescent

Adult

Female

Brain Damage, Chronic - pathology

Child

Epilepsy, Temporal Lobe - pathology

Details

Title: Subtitle: Neurodevelopmental vulnerability of the corpus callosum to childhood onset localization-related epilepsy
Creators: Bruce Hermann - Department of Neurology, University of Wisconsin, Madison, WI 53792, USA. hermann@neurology.wisc.edu
Russ Hansen
Michael Seidenberg
Vince Magnotta
Dan O'Leary
Resource Type: Journal article
Publication Details: NeuroImage (Orlando, Fla.), Vol.18(2), pp.284-292
DOI: 10.1016/S1053-8119(02)00044-7
PMID: 12595183
NLM abbreviation: Neuroimage
ISSN: 1053-8119
eISSN: 1095-9572
Publisher: United States
Grant note: M01 RR 03186 / NCRR NIH HHS R01 NS 37738 / NINDS NIH HHS
Language: English
Date published: 02/2003
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Psychiatry; Iowa Neuroscience Institute
Record Identifier: 9984003488802771

Metrics

25 Record Views

58 Times Cited - Web of Science