Journal article
Neuroendocrine influences on cancer progression
Brain, behavior, and immunity, Vol.30(Suppl), pp.S19-S25
03/15/2013
DOI: 10.1016/j.bbi.2012.06.005
PMCID: PMC3467346
PMID: 22728325
Abstract
► The role of neuroendocrine factors in cancer initiation remains poorly understood and primed for further investigation. ► Neuroendocrine stress mediators can modulate key cellular and molecular processes that lead to cancer progression. ► Psychosocial interventions and pharmacological approaches hold promise as potential adjuvant therapy for cancer patients.
During the past decade, new studies have continued to shed light on the role of neuroendocrine regulation of downstream physiological and biological pathways relevant to cancer growth and progression. More specifically, our knowledge of the effects of the sympathetic nervous system (SNS) on cancer biology has been greatly expanded by new data demonstrating how the cellular immune response, inflammatory processes, tumor-associated angiogenesis, and tumor cell invasion and survival converge to promote tumor growth. This review will summarize these studies, while synthesizing clinical, cellular and molecular research that has continued to unearth the biological events mediating the interplay between SNS-related processes and cancer progression.
Details
- Title: Subtitle
- Neuroendocrine influences on cancer progression
- Creators
- Guillermo N Armaiz-Pena - Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas, United StatesSteve W Cole - Department of Medicine, Division of Hematology–Oncology, UCLA School of Medicine, Los Angeles, California, United StatesSusan K Lutgendorf - Departments of Psychology, Urology, Obstetrics and Gynecology, and the Holden Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa, United StatesAnil K Sood - Departments of Gynecologic Oncology, Cancer Biology and Center for RNA Interference and Non-coding RNA, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States
- Resource Type
- Journal article
- Publication Details
- Brain, behavior, and immunity, Vol.30(Suppl), pp.S19-S25
- DOI
- 10.1016/j.bbi.2012.06.005
- PMID
- 22728325
- PMCID
- PMC3467346
- NLM abbreviation
- Brain Behav Immun
- ISSN
- 0889-1591
- eISSN
- 1090-2139
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 03/15/2013
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute; Obstetrics and Gynecology; Urology
- Record Identifier
- 9984065882802771
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