Journal article
Neuroimaging Correlates of Post-Traumatic Stress Disorder in Traumatic Brain Injury: A Systematic Review of the Literature
Journal of neurotrauma, Vol.40(11-12), pp.1029-1044
06/2023
DOI: 10.1089/neu.2021.0453
PMCID: PMC10402701
PMID: 36259461
Abstract
Neuroimaging is widely utilized in studying traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD). The risk for PTSD is greater after TBI than non-TBI trauma, and PTSD is associated with worse outcomes after TBI. Studying the neuroimaging correlates of TBI-related PTSD may provide insights into the etiology of both conditions and help identify those TBI patients most at risk of developing persistent symptoms. The objectives of this systematic review were to examine the current literature on neuroimaging in TBI-related PTSD, summarize key findings, and highlight strengths and limitations to guide future research. A PRISMA compliant literature search was conducted in PubMed (MEDLINE), PsychINFO, EMBASE, and Scopus databases prior to January 2022. The database query yielded 4486 articles, which were narrowed based on specified inclusion criteria to a final cohort of 16 studies, comprised of 854 participants with TBI. There was no consensus regarding neuroimaging correlates of TBI-related PTSD among the included articles. A small number of studies suggest that TBI-related PTSD is associated with white matter tract changes, particularly in frontotemporal regions, as well as changes in whole-brain networks of resting-state connectivity. Future studies hoping to identify reliable neuroimaging correlates of TBI-related PTSD would benefit from ensuring consistent case definition, preferably with clinician diagnosed TBI and PTSD, selection of comparable control groups, and attention to imaging timing post-injury. Prospective studies are needed and should aim to further differentiate predisposing factors from sequelae of TBI-related PTSD.
Details
- Title: Subtitle
- Neuroimaging Correlates of Post-Traumatic Stress Disorder in Traumatic Brain Injury: A Systematic Review of the Literature
- Creators
- Aaron I Esagoff - Johns Hopkins MedicineDaniel A Stevens - Johns Hopkins MedicineNatalia Kosyakova - University of ConnecticutKaylee Woodard - Louisiana State University Health Sciences Center New OrleansDiane Jung - Johns Hopkins MedicineLisa N. Richey - Johns Hopkins MedicineNicholas O Daneshvari - Johns Hopkins MedicineLicia P Luna - Johns Hopkins MedicineMichael J.C. Bray - Johns Hopkins MedicineBarry R. Bryant - Johns Hopkins MedicineCarla P Rodriguez - Johns Hopkins MedicineAkshay Krieg - Johns Hopkins MedicineNicholas T Trapp - Roy J. and Lucille A. Carver College of MedicineMelissa B Jones - Michael E. DeBakey VA Medical CenterCarrie Roper - VA Maryland Health Care SystemEric L Goldwaser - University of Maryland, BaltimoreEmily Berich-Anastasio - Sheppard Pratt Health SystemAlexandra Pletnikova - Johns Hopkins MedicineKatie Lobner - Johns Hopkins UniversityMargo Lauterbach - University of Maryland, BaltimoreHaris I. Sair - Johns Hopkins MedicineMatthew E Peters - Johns Hopkins Medicine
- Resource Type
- Journal article
- Publication Details
- Journal of neurotrauma, Vol.40(11-12), pp.1029-1044
- DOI
- 10.1089/neu.2021.0453
- PMID
- 36259461
- PMCID
- PMC10402701
- NLM abbreviation
- J Neurotrauma
- ISSN
- 0897-7151
- eISSN
- 1557-9042
- Language
- English
- Electronic publication date
- 2022
- Date published
- 06/2023
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984305982502771
Metrics
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