Journal article
Neuroinflammation in glaucoma: A new opportunity
Experimental Eye Research, Vol.157, pp.20-27
04/2017
DOI: 10.1016/j.exer.2017.02.014
PMCID: PMC5497582
PMID: 28242160
Abstract
Mounting evidence suggests neuroinflammation is a key process in glaucoma, yet the precise roles are not known. Understanding these complex processes, which may also be a key in other common neurodegenerations such as Alzheimer's disease, will lead to targeted therapeutics for a disease that affects as many as 80 million people worldwide. Here, we define neuroinflammation as any immune-relevant response by a variety of cell types including astrocytes, microglia, and peripherally derived cells occurring in the optic nerve head and/or retina. In this review article, we first discuss clinical evidence for neuroinflammation in glaucoma and define neuroinflammation in glaucoma. We then review the inflammatory pathways that have been associated with glaucoma. Finally, we set out key research directions that we believe will greatly advance our understanding of the role of neuroinflammation in glaucoma. This review arose from a discussion of neuroinflammation in glaucoma at the 2015 meeting of The Lasker/IRRF Initiative for Innovation in Vision Science. This manuscript sets out to summarize one of these sessions; “Inflammation and Glaucomatous Neurodegeneration”, as well as to review the current state of the literature surrounding neuroinflammation in glaucoma. •We describe the clinical relevance of inflammation in glaucoma.•We define the sites of neuroinflammation in glaucoma.•We discuss the roles of different cells and pathways in glaucoma.•We discuss suggested 5 year goals as set about by the participants of the 2015 Lasker/IRRF Initiative session “Inflammation and Glaucomatous Neurodegeneration”.
Details
- Title: Subtitle
- Neuroinflammation in glaucoma: A new opportunity
- Creators
- Pete A Williams - The Jackson Laboratory, Bar Harbor, ME, USANick Marsh-Armstrong - The Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD, USAGareth R Howell - The Jackson Laboratory, Bar Harbor, ME, USAAlejandra Bosco - University of Utah, School of Medicine, Salt Lake City, UT, USAJohn Danias - Department of Ophthalmology, SUNY Downstate, NY, USAJohn Simon - The Jackson Laboratory, Bar Harbor, ME, USAAdriana Di Polo - Department of Neuroscience and Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Université de Montréal, Montréal, Québec, CanadaMarkus H Kuehn - Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, IA, USASerge Przedborski - Departments of Pathology & Cell Biology, Columbia University Medical Center, NY, USAMartin Raff - MRC Laboratory for Molecular Cell Biology, University College London, London, UKIan Trounce - Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, East Melbourne, Victoria, AustraliaThe Lasker/IRRF Initiative on Astrocytes and Glaucomatous Neurodegeneration Participants
- Resource Type
- Journal article
- Publication Details
- Experimental Eye Research, Vol.157, pp.20-27
- DOI
- 10.1016/j.exer.2017.02.014
- PMID
- 28242160
- PMCID
- PMC5497582
- NLM abbreviation
- Exp Eye Res
- ISSN
- 0014-4835
- eISSN
- 1096-0007
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 04/2017
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9983979972402771
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