Journal article
Neurological Complications in Patients with Systemic Lupus Erythematosus
Current neurology and neuroscience reports, Vol.19(12), pp.1-10
12/2019
DOI: 10.1007/s11910-019-1012-1
PMID: 31773306
Abstract
Systemic lupus erythematosus (SLE) is commonly associated with neurological manifestations. Rapid recognition and treatment of these complications may improve outcomes. In this article, we review the neurological conditions associated with SLE, their diagnosis and management strategies.Recent meta-analysis showed that patients with neuropsychiatric manifestations of SLE were more likely to have positive antiphospholipid, antiribosomal P, and antineuronal antibodies. Another meta-analysis showed an association between SLE and antiphospholipid antibodies with cognitive impairment. Two large retrospective studies have shown that the peripheral nervous system is commonly involved in SLE frequently alongside the central nervous system.Neurological manifestations occur in most of SLE patients. Antiphospholipid antibodies are common in patients with SLE and increase the odds of neurological complications. Management typically involved a combination of treatments directed toward the neurological complication and therapies directed toward SLE itself. The efficacy of these treatment protocols, however, has not been rigorously studied and deserves further investigation.
Details
- Title: Subtitle
- Neurological Complications in Patients with Systemic Lupus Erythematosus
- Creators
- Amir Shaban - 0000 0004 1936 8294 grid.214572.7 Department of Neurology, Carver College of Medicine University of Iowa 200 Hawkins Dr. Iowa City IA 52242 USAEnrique Leira - 0000 0004 1936 8294 grid.214572.7 Department of Epidemiology, College of Public Health University of Iowa Iowa City IA USA
- Resource Type
- Journal article
- Publication Details
- Current neurology and neuroscience reports, Vol.19(12), pp.1-10
- Publisher
- Springer US; New York
- DOI
- 10.1007/s11910-019-1012-1
- PMID
- 31773306
- ISSN
- 1528-4042
- eISSN
- 1534-6293
- Language
- English
- Date published
- 12/2019
- Academic Unit
- Neurology; Epidemiology; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984070716002771
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