Neurological abnormalities in familial and sporadic schizophrenia

T. D Griffiths; T Sigmundsson; N Takei; D Rowe; R. M Murray

doi:10.1093/brain/121.2.191

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Neurological abnormalities in familial and sporadic schizophrenia

Journal article

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Neurological abnormalities in familial and sporadic schizophrenia

T. D Griffiths, T Sigmundsson, N Takei, D Rowe and R. M Murray

Brain (London, England : 1878), Vol.121(2), pp.191-203

02/01/1998

DOI: 10.1093/brain/121.2.191

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Abstract

Neurological assessment was carried out on patients with schizophrenia from multiply and singly affected families, their relatives, and a normal control group (214 subjects). A systematic examination was used in which abnormal signs were divided into 'primary' and 'integrative' signs. Primary signs were elicited by a standard clinical neurological examination and included signs of focal damage to nuclei and tracts, whilst integrative signs were selected as reflecting distributed brain function. The assessments were carried out to test the hypotheses that (i) neurological abnormalities are present in schizophrenia, (ii) the pattern of abnormality is different in familial and sporadic schizophrenic subjects, and (iii) the well relatives of familial (but not sporadic) schizophrenic subjects will show neurological abnormalities. An excess of primary signs compared with the controls was demonstrated in the sporadic schizophrenic group only. Both the familial schizophrenics and their first-degree relatives (but not their sporadic counterparts) showed an increase in integrative signs. The results support the existence of different mechanisms of underlying brain dysfunction in familial and sporadic schizophrenia.

Schizophrenia

Adult and adolescent clinical studies

Biological and medical sciences

Medical sciences

Psychology. Psychoanalysis. Psychiatry

Psychopathology. Psychiatry

Psychoses

Details

Title: Subtitle: Neurological abnormalities in familial and sporadic schizophrenia
Creators: T. D Griffiths - Newcastle University
T Sigmundsson - Department of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
N Takei - Department of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
D Rowe - National Hospital for Neurology, London, United Kingdom
R. M Murray - Department of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
Resource Type: Journal article
Publication Details: Brain (London, England : 1878), Vol.121(2), pp.191-203
Publisher: Oxford University Press
DOI: 10.1093/brain/121.2.191
ISSN: 0006-8950
eISSN: 1460-2156
Language: English
Date published: 02/01/1998
Academic Unit: Psychological and Brain Sciences
Record Identifier: 9984627315602771

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