Journal article
Neurological and psychiatric aspects of emotion
Handbook of clinical neurology, Vol.106, pp.53-74
2012
DOI: 10.1016/B978-0-444-52002-9.00004-8
PMID: 22608615
Abstract
Neurological and psychiatric aspects of emotions have been the focus of intense research for the past 30 years. Studies in both acute (e.g., stroke, traumatic brain injury (TBI)) and chronic (e.g., dementia, Parkinson's disease) neurological disorders demonstrated a high frequency of both depression and apathy. Studies in stroke and TBI reported a significant association between lesion location and depression. Both depression and apathy are significant predictors of poor recovery among patients with brain injuries, and of steeper cognitive and functional decline among patients with neurodegenerative disorders. Poor insight and judgment are frequently found among patients with brain injury or degeneration. There is increasing evidence that damage to specific brain regions, such as the ventromedial prefrontal cortex, is associated with inappropriate emotional reactions in social contexts and diminished anxiety and concern for the future. In severe cases, behavioural changes may also include poor decision-making in the social realm, deficits in goal-directed behavior, and lack of insight into these changes. Future studies will validate specific diagnostic criteria for the various cognitive, emotional, and behavioral problems reported among patients with neurological disorders, which may result in more specific and effective treatments.
Details
- Title: Subtitle
- Neurological and psychiatric aspects of emotion
- Creators
- Sergio E Starkstein - School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Australia. ses@meddent.uwa.edu.auDaniel Tranel
- Resource Type
- Journal article
- Publication Details
- Handbook of clinical neurology, Vol.106, pp.53-74
- DOI
- 10.1016/B978-0-444-52002-9.00004-8
- PMID
- 22608615
- NLM abbreviation
- Handb Clin Neurol
- ISSN
- 0072-9752
- Publisher
- Netherlands
- Grant note
- P50 NS19632 / NINDS NIH HHS R01 DA022549 / NIDA NIH HHS
- Language
- English
- Date published
- 2012
- Academic Unit
- Neurology; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984002446802771
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