Journal article
Neurological involvement of coronavirus disease 2019: a systematic review
Journal of neurology, Vol.267(11), pp.3135-3153
11/01/2020
DOI: 10.1007/s00415-020-09990-2
PMCID: PMC7304377
PMID: 32561990
Abstract
Background In December 2019, unexplained cases of pneumonia emerged in Wuhan, China, which were found to be secondary to the novel coronavirus SARS-CoV-2. On March 11, 2020, the WHO declared the Coronavirus Disease 2019 (COVID-2019) outbreak, a pandemic. Objective To clarify the neurological complications of SARS-CoV-2 infection including the potential mechanisms and therapeutic options. Methods We conducted a systematic literature search from December 01, 2019 to May 14, 2020 using multiple combinations of keywords from PubMed and Ovid Medline databases according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We included articles with cases of COVID-19 where neurological involvement was evident. Results We were able to identify 82 cases of COVID-19 with neurological complications. The mean age was 62.3 years. 37.8% of the patients were women (n = 31). 48.8% of the patients (n = 40) had cerebrovascular insults, 28% (n = 23) had neuromuscular disorders, and 23% of the patients (n = 19) had encephalitis or encephalopathy. Conclusions Neurological manifestations of COVID-19 are not rare, especially large vessel stroke, Guillain-Barre syndrome, and meningoencephalitis. Moving forward, further studies are needed to clarify the prevalence of the neurological complications of SARS-CoV-2 infection, investigate their biological backgrounds, and test treatment options. Physicians should be cautious not to overlook other neurological diagnoses that can mimic COVID-19 during the pandemic.
Details
- Title: Subtitle
- Neurological involvement of coronavirus disease 2019: a systematic review
- Creators
- Malik Ghannam - University of MinnesotaQasem Alshaer - Emory UniversityMustafa Al-Chalabi - University of ToledoLara Zakarna - An-Najah National UniversityJetter Robertson - University of MinnesotaGeorgios Manousakis - University of Minnesota
- Resource Type
- Journal article
- Publication Details
- Journal of neurology, Vol.267(11), pp.3135-3153
- Publisher
- Springer Nature
- DOI
- 10.1007/s00415-020-09990-2
- PMID
- 32561990
- PMCID
- PMC7304377
- ISSN
- 0340-5354
- eISSN
- 1432-1459
- Number of pages
- 19
- Language
- English
- Date published
- 11/01/2020
- Academic Unit
- Neurology
- Record Identifier
- 9984640714502771
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