Journal article
Neurolymphomatosis mimicking chemotherapy-induced ototoxicity
Otology & neurotology, Vol.30(4), pp.566-569
06/2009
DOI: 10.1097/MAO.0b013e3181a527b2
PMID: 19415035
Abstract
To present an unusual cause of bilateral sensorineural hearing loss mimicking chemotherapy-induced ototoxicity.
A 76-year-old woman with bilateral sudden sensorineural hearing loss after chemotherapy for non-Hodgkin lymphoma was referred for cochlear implantation.
Prednisone and acyclovir were administered empirically during the course of the diagnostic evaluation.
Diagnostic tests were obtained, including audiometry, positron emission tomography/computed tomographic imaging, and magnetic resonance imaging scan of the brain with gadolinium.
Audiometry revealed bilateral profound sensorineural hearing loss without improvement after steroid and acyclovir treatment. Postchemotherapy positron emission tomography/computed tomographic imaging obtained 1 week after onset of hearing loss suggested the lymphoma to be in remission. However, magnetic resonance imaging obtained a few weeks later, concurrent with progression of symptoms to include facial palsy and numbness, demonstrated enhancement and thickening of multiple cranial nerves, consistent with neurolymphomatosis (malignant lymphocytic infiltration of nerves).
Particular vigilance must be given to the potential for malignant invasion of the peripheral nervous system in the context of new-onset sensorineural hearing loss after chemotherapy. Such a neurologic deficit should not be assumed to be chemotherapy induced even if the hearing loss is bilaterally symmetric and the only neurologic abnormality.
Details
- Title: Subtitle
- Neurolymphomatosis mimicking chemotherapy-induced ototoxicity
- Creators
- Robert S Hong - Department of Otolaryngology-Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA. Robert-hong@uiowa.eduErika A WoodsonMarlan R Hansen
- Resource Type
- Journal article
- Publication Details
- Otology & neurotology, Vol.30(4), pp.566-569
- Publisher
- United States
- DOI
- 10.1097/MAO.0b013e3181a527b2
- PMID
- 19415035
- ISSN
- 1531-7129
- eISSN
- 1537-4505
- Language
- English
- Date published
- 06/2009
- Academic Unit
- Molecular Physiology and Biophysics; Neurosurgery; Otolaryngology
- Record Identifier
- 9984006409802771
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