Journal article
Neuromyotonia 2003
Aktuelle Neurologie, Vol.30(10), pp.502-504
12/01/2003
Abstract
Neuromyotonia clinically shows muscle cramps, stiffness, and slowing of movements due to continuous muscle fiber activity. The discharges originate from hyperexcitability of peripheral nerve. Electromyographically, the motor units discharge repetitively or in bursts as observed in myokymia. The disorder is mainly aquired for example by demyelination, autoimmune reaction, x-ray therapy, and toxins but also occurs as a genetic abnormality. The pathophysiological basis is a dysfunction of the axon membrane frequently associated with changes of the voltage gated K+-channels. Carbamazepine and phenytoin reduces the abnormal muscle activity. An immunosuppressive treatment with corticosteroids, Azathioprin, and plasma separation may be effective.
Details
- Title: Subtitle
- Neuromyotonia 2003
- Creators
- L GutmannH C Hopf
- Resource Type
- Journal article
- Publication Details
- Aktuelle Neurologie, Vol.30(10), pp.502-504
- Publisher
- Thieme Medical Publishers
- ISSN
- 0302-4350
- eISSN
- 1438-9428
- Number of pages
- 3
- Language
- German
- Date published
- 12/01/2003
- Academic Unit
- Neurology
- Record Identifier
- 9984303558902771
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