Neuronal IL-17 controls Caenorhabditis elegans developmental diapause through CEP-1/p53

Abhishiktha Godthi; Sehee Min; Srijit Das; Johnny Cruz-Corchado; Andrew Deonarine; Kara Misel-Wuchter; Priya D Issuree; Veena Prahlad

doi:10.1073/pnas.2315248121

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Neuronal IL-17 controls Caenorhabditis elegans developmental diapause through CEP-1/p53

Journal article

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Neuronal IL-17 controls Caenorhabditis elegans developmental diapause through CEP-1/p53

Abhishiktha Godthi, Sehee Min, Srijit Das, Johnny Cruz-Corchado, Andrew Deonarine, Kara Misel-Wuchter, Priya D Issuree and Veena Prahlad

Proceedings of the National Academy of Sciences - PNAS, Vol.121(12), e2315248121

03/19/2024

DOI: 10.1073/pnas.2315248121

PMCID: PMC10963014

PMID: 38483995

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Abstract

During metazoan development, how cell division and metabolic programs are coordinated with nutrient availability remains unclear. Here, we show that nutrient availability signaled by the neuronal cytokine, ILC-17.1, switches development between reproductive growth and dormancy by controlling the activity of the tumor suppressor p53 ortholog, CEP-1. Specifically, upon food availability, ILC-17.1 signaling by amphid neurons promotes glucose utilization and suppresses CEP-1/p53 to allow growth. In the absence of ILC-17.1, CEP-1/p53 is activated, up-regulates cell-cycle inhibitors, decreases phosphofructokinase and cytochrome C expression, and causes larvae to arrest as stress-resistant, quiescent dauers. We propose a model whereby ILC-17.1 signaling links nutrient availability and energy metabolism to cell cycle progression through CEP-1/p53. These studies describe ancestral functions of IL-17 s and the p53 family of proteins and are relevant to our understanding of neuroimmune mechanisms in cancer. They also reveal a DNA damage-independent function of CEP-1/p53 in invertebrate development and support the existence of a previously undescribed dauer pathway.

immunometabolomic

C. elegans

p53/cep-1

IL-17

dauer

Details

Title: Subtitle: Neuronal IL-17 controls Caenorhabditis elegans developmental diapause through CEP-1/p53
Creators: Abhishiktha Godthi - Department of Biology, The University of Iowa, Iowa City, IA 52242-1324
Sehee Min - Department of Biology, The University of Iowa, Iowa City, IA 52242-1324
Srijit Das - Department of Biology, The University of Iowa, Iowa City, IA 52242-1324
Johnny Cruz-Corchado - Department of Biology, The University of Iowa, Iowa City, IA 52242-1324
Andrew Deonarine - Department of Biology, The University of Iowa, Iowa City, IA 52242-1324
Kara Misel-Wuchter - Department of Internal Medicine, The University of Iowa, Iowa City, IA 52242
Priya D Issuree - Department of Internal Medicine, The University of Iowa, Iowa City, IA 52242
Veena Prahlad - University of Iowa
Resource Type: Journal article
Publication Details: Proceedings of the National Academy of Sciences - PNAS, Vol.121(12), e2315248121
DOI: 10.1073/pnas.2315248121
PMID: 38483995
PMCID: PMC10963014
NLM abbreviation: Proc Natl Acad Sci U S A
eISSN: 1091-6490
Grant note: R01 AG060616 / NIA NIH HHS
Language: English
Date published: 03/19/2024
Academic Unit: Microbiology and Immunology; Infectious Diseases; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Biology; Internal Medicine
Record Identifier: 9984573459702771

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