Neuronal activity and adenylyl cyclase in environment-dependent plasticity of axonal outgrowth in Drosophila

Yi Zhong; Chun-Fang Wu

doi:10.1523/JNEUROSCI.0740-02.2004

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Neuronal activity and adenylyl cyclase in environment-dependent plasticity of axonal outgrowth in Drosophila

Journal article

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Neuronal activity and adenylyl cyclase in environment-dependent plasticity of axonal outgrowth in Drosophila

Yi Zhong and Chun-Fang Wu

The Journal of neuroscience, Vol.24(6), pp.1439-1445

02/11/2004

DOI: 10.1523/JNEUROSCI.0740-02.2004

PMCID: PMC1289273

PMID: 14960616

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Abstract

The development of the nervous system is influenced by environmental factors. Among all environmental factors, temperature belongs to a unique category. Besides activating some specific sensory pathways, it exerts nonspecific, pervasive effects directly on the entire nervous system, especially in exothermic species. This study uses mutants to genetically discover how temperature affects nerve terminal arborization at larval neuromuscular junctions of Drosophila. It is known that hyperexcitability in K(+) channel mutants leads to enhanced ramification of larval nerve terminals. Elevated cAMP levels in dunce mutants with reduced phosphodiesterase activity also cause enhanced arborization. These genetic alterations are thought to perturb mechanisms relevant to activity-dependent neural plasticity, in which neuronal activity activates the cAMP pathway, and consequently affect nerve terminal arborization by regulating expression of adhesion molecules. Here we demonstrate the robust influence of rearing temperature on motor nerve terminal arborization. Analysis of ion channel and cAMP pathway mutants indicates that this temperature-dependent plasticity is mediated via neuronal activity changes linked to mechanisms controlled by the rutabaga-encoded adenylyl cyclase.

Motor Neurons - physiology

Temperature

Synaptic Transmission - physiology

Axons - physiology

Presynaptic Terminals - physiology

Adenylyl Cyclases - metabolism

Motor Neurons - enzymology

Drosophila Proteins - metabolism

Drosophila - physiology

Animals

Neuronal Plasticity - physiology

Axons - ultrastructure

Environment

Drosophila Proteins - genetics

Larva - physiology

Mutation

Adenylyl Cyclases - genetics

Transgenes

Drosophila - genetics

Details

Title: Subtitle: Neuronal activity and adenylyl cyclase in environment-dependent plasticity of axonal outgrowth in Drosophila
Creators: Yi Zhong - Department Biological Sciences, University of Iowa, Iowa City, Iowa 52242, USA. zhongyi@cshl.org
Chun-Fang Wu
Resource Type: Journal article
Publication Details: The Journal of neuroscience, Vol.24(6), pp.1439-1445
Publisher: United States
DOI: 10.1523/JNEUROSCI.0740-02.2004
PMID: 14960616
PMCID: PMC1289273
ISSN: 0270-6474
eISSN: 1529-2401
Grant note: R01 NS026528 / NINDS NIH HHS R01 NS034779 / NINDS NIH HHS NS34779 / NINDS NIH HHS NS26528 / NINDS NIH HHS
Language: English
Date published: 02/11/2004
Academic Unit: Iowa Neuroscience Institute; Biology
Record Identifier: 9984070867802771

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