Journal article
Neuronal correlates of post-error slowing in the rat dorsomedial prefrontal cortex
Journal of neurophysiology, Vol.100(1), pp.520-525
07/2008
DOI: 10.1152/jn.00035.2008
PMCID: PMC2493486
PMID: 18480374
Abstract
Rats with impaired function in dorsomedial regions of the prefrontal cortex (dmPFC) are unable to maintain a behavioral response over a delay period. Here we report that neurons in this cortical region are prominently modulated after errors in a tone-cued, simple reaction time task and that inactivation of dmPFC attenuates a slowing of reaction times that is observed following errors. Using methods for chronic single-unit recording, we found that approximately one-third of dmPFC neurons were modulated after errors, and 28% of these neurons had increased posterror firing that persisted into the delay period of the following trial. In contrast to dmPFC, no such neurons were found in motor cortex. Our results implicate the dorsomedial prefrontal cortex in a form of retrospective working memory that improves task performance following errors.
Details
- Title: Subtitle
- Neuronal correlates of post-error slowing in the rat dorsomedial prefrontal cortex
- Creators
- Nandakumar S Narayanan - The John B Pierce Laboratory, Yale University School of Medicine, New Haven, Connecticut, USAMark Laubach
- Resource Type
- Journal article
- Publication Details
- Journal of neurophysiology, Vol.100(1), pp.520-525
- DOI
- 10.1152/jn.00035.2008
- PMID
- 18480374
- PMCID
- PMC2493486
- NLM abbreviation
- J Neurophysiol
- ISSN
- 0022-3077
- eISSN
- 1522-1598
- Publisher
- United States
- Language
- English
- Date published
- 07/2008
- Academic Unit
- Neurology; Iowa Neuroscience Institute
- Record Identifier
- 9984020739502771
Metrics
12 Record Views