Neuronal modulation of Schwann cell glial fibrillary acidic protein (GFAP)

K MOKUNO; J KAMHOLZ; T BEHRMAN; C BLACK; M SESSA; D FEINSTEIN; V LEE; D PLEASURE

doi:10.1002/jnr.490230405

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Neuronal modulation of Schwann cell glial fibrillary acidic protein (GFAP)

Journal article

Peer reviewed

Neuronal modulation of Schwann cell glial fibrillary acidic protein (GFAP)

K MOKUNO, J KAMHOLZ, T BEHRMAN, C BLACK, M SESSA, D FEINSTEIN, V LEE and D PLEASURE

Journal of neuroscience research, Vol.23(4), pp.396-405

1989

DOI: 10.1002/jnr.490230405

PMID: 2769798

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Abstract

Adult rat sciatic nerves contain cytoskeletal peptides that resemble CNS glial fibrillary acidic protein (GFAP) in immunoreactivity and molecular weight. Immunohistological examination of teased nerve fascicles indicated that these peptides are expressed selectively by Schwann cells related to small axons. Radiolabelled mouse and rat CNS GFAP cDNA probes hybridized with a single, 2.7 kb RNA band in Northern blots prepared from total RNA from both rat sciatic nerve and rat brain. Sciatic nerve GFAP mRNA was detectable by this means in adult, 2 month, or 21 day postnatal rats, but not in 3, 6, or 10 day postnatal rats. Sciatic nerve transection caused a marked reduction in the level of GFAP mRNA in the axotomized distal stump. We conclude that Schwann cell synthesis of GFAP is developmentally regulated and that Schwann cells, unlike astroglia, require continued trophic input from small axons in order to express GFAP.

Fundamental and applied biological sciences. Psychology

Vertebrates: nervous system and sense organs

Biological and medical sciences

Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ

Details

Title: Subtitle: Neuronal modulation of Schwann cell glial fibrillary acidic protein (GFAP)
Creators: K MOKUNO - Children's hosp. Philadelphia, neurology res., Philadelphia PA 19104, United States
J KAMHOLZ - Children's hosp. Philadelphia, neurology res., Philadelphia PA 19104, United States
T BEHRMAN - Children's hosp. Philadelphia, neurology res., Philadelphia PA 19104, United States
C BLACK - Children's hosp. Philadelphia, neurology res., Philadelphia PA 19104, United States
M SESSA - Children's hosp. Philadelphia, neurology res., Philadelphia PA 19104, United States
D FEINSTEIN - Children's hosp. Philadelphia, neurology res., Philadelphia PA 19104, United States
V LEE - Children's hosp. Philadelphia, neurology res., Philadelphia PA 19104, United States
D PLEASURE - Children's hosp. Philadelphia, neurology res., Philadelphia PA 19104, United States
Resource Type: Journal article
Publication Details: Journal of neuroscience research, Vol.23(4), pp.396-405
Publisher: Wiley-Liss; New York, NY
DOI: 10.1002/jnr.490230405
PMID: 2769798
ISSN: 0360-4012
eISSN: 1097-4547
Language: English
Date published: 1989
Academic Unit: Neurology; Psychiatry
Record Identifier: 9984020716702771

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