Neurons in human pre-supplementary motor area encode key computations for value-based choice

Tomas G Aquino; Jeffrey Cockburn; Adam N Mamelak; Ueli Rutishauser; John P O'Doherty

doi:10.1038/s41562-023-01548-2

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Neurons in human pre-supplementary motor area encode key computations for value-based choice

Journal article

Peer reviewed

Neurons in human pre-supplementary motor area encode key computations for value-based choice

Tomas G Aquino, Jeffrey Cockburn, Adam N Mamelak, Ueli Rutishauser and John P O'Doherty

Nature human behaviour, Vol.7(6), pp.970-985

06/01/2023

DOI: 10.1038/s41562-023-01548-2

PMCID: PMC10330469

PMID: 36959327

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https://pmc.ncbi.nlm.nih.gov/articles/PMC10330469/pdf/nihms-1902916.pdfView

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Abstract

Adaptive behaviour in real-world environments requires that choices integrate several variables, including the novelty of the options under consideration, their expected value and uncertainty in value estimation. Here, to probe how integration over decision variables occurs during decision-making, we recorded neurons from the human pre-supplementary motor area (preSMA), ventromedial prefrontal cortex and dorsal anterior cingulate. Unlike the other areas, preSMA neurons not only represented separate pre-decision variables for each choice option but also encoded an integrated utility signal for each choice option and, subsequently, the decision itself. Post-decision encoding of variables for the chosen option was more widely distributed and especially prominent in the ventromedial prefrontal cortex. Our findings position the human preSMA as central to the implementation of value-based decisions.

Choice Behavior - physiology

Gyrus Cinguli - physiology

Humans

Motor Cortex

Neurons - physiology

Prefrontal Cortex - physiology

Details

Title: Subtitle: Neurons in human pre-supplementary motor area encode key computations for value-based choice
Creators: Tomas G Aquino - California Institute of Technology
Jeffrey Cockburn - California Institute of Technology
Adam N Mamelak - Cedars-Sinai Medical Center
Ueli Rutishauser - Cedars-Sinai Medical Center
John P O'Doherty - Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA, USA
Resource Type: Journal article
Publication Details: Nature human behaviour, Vol.7(6), pp.970-985
DOI: 10.1038/s41562-023-01548-2
PMID: 36959327
PMCID: PMC10330469
NLM abbreviation: Nat Hum Behav
ISSN: 2397-3374
eISSN: 2397-3374
Grant note: R01 DA040011 / NIDA NIH HHS R01 MH133729 / NIMH NIH HHS R01 MH110831 / NIMH NIH HHS R01 MH111425 / NIMH NIH HHS U01 NS103792 / NINDS NIH HHS U01 NS117839 / NINDS NIH HHS P50 MH094258 / NIMH NIH HHS
Language: English
Date published: 06/01/2023
Academic Unit: Psychological and Brain Sciences
Record Identifier: 9984696756202771

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