Journal article
Neuropathological correlates of dysarthria in progressive supranuclear palsy
Archives of neurology (Chicago), Vol.58(2), pp.265-269
2001
DOI: 10.1001/archneur.58.2.265
PMID: 11176965
Abstract
Background: The dysarthria of progressive supranuclear palsy consists of prominent hypokinetic and spastic components with less prominent ataxic components.
Objective: To correlate the types of dysarthria with neuropathological changes in patients with progressive supranuclear palsy.
Design and methods: In 14 patients with progressive supranuclear palsy, we correlated the perceptual speech findings with the neuropathological findings. A dysarthria assessment was performed a mean +/- SD of 31 +/- 15 months (range, 10-53 months) before death. The deviant speech dimensions were rated on a scale of 0 (normal) to 3 (severe). The neuropathological examination consisted of semiquantitative analysis of neuronal loss and gliosis by investigators (A.A.F.S., and L.A.B.) blinded to the clinical findings. Correlation and linear regression analysis were used to correlate the severity of the hypokinetic, spastic, and ataxic components with the degree of neuronal loss and gliosis in predetermined anatomical sites.
Results: All patients had hypokinetic and spastic dysarthria, and 9 also had ataxic components. The severity of the hypokinetic components was significantly correlated with the degree of neuronal loss and gliosis in the substantia nigra pars compacta (r = 0.61, P =.02) and pars reticulata (r = 0.64, P =.01) but not in the subthalamic nucleus (r = 0.51, P =.07) or the striatum or globus pallidus (/r/<0.34, P>.20). The severity of the spastic and ataxic components was not significantly correlated with the neuropathological changes in the frontal cortex (r = 0.20, P =.50) and cerebellum (/r/<0.28, P>.33), respectively.
Conclusion: The hypokinetic dysarthria of progressive supranuclear palsy may result from degenerative changes in the substantia nigra pars compacta and pars reticulata and not from changes in the striatum or globus pallidus.
Details
- Title: Subtitle
- Neuropathological correlates of dysarthria in progressive supranuclear palsy
- Creators
- Karen J KLUIN - Department of Spcech-Language Pathology, University of Michigan Health System, Ann Arbor, United StatesSid GILMAN - Department of Neurology, University of Michigan Health System, Ann Arbor, United StatesNorman L FOSTER - Department of Neurology, University of Michigan Health System, Ann Arbor, United StatesAnders A. F SIMA - Department of Pathology, University of Michigan Health System, Ann Arbor, United StatesConstance J D'AMATO - Department of Pathology, University of Michigan Health System, Ann Arbor, United StatesLeslie A BRUCH - Department of Pathology and Microbiology, University of Nebraska, Omaha, United StatesLaurie BLUEMLEIN - Department of Neurology, University of Michigan Health System, Ann Arbor, United StatesRoderick LITTLE - Department of Biostatistics, University of Michigan Health System, Ann Arbor, United StatesJewel JOHANNS - Department of Biostatistics, University of Michigan Health System, Ann Arbor, United States
- Resource Type
- Journal article
- Publication Details
- Archives of neurology (Chicago), Vol.58(2), pp.265-269
- DOI
- 10.1001/archneur.58.2.265
- PMID
- 11176965
- NLM abbreviation
- Arch Neurol
- ISSN
- 0003-9942
- eISSN
- 1538-3687
- Publisher
- American Medical Association; Chicago, IL
- Language
- English
- Date published
- 2001
- Academic Unit
- Pathology; Neurosurgery
- Record Identifier
- 9984040371302771
Metrics
11 Record Views