Journal article
Neuropathy among the diabetes control and complications trial cohort 8 years after trial completion
Diabetes care, Vol.29(2), pp.340-344
02/2006
DOI: 10.2337/diacare.29.02.06.dc05-1549
PMCID: PMC2622720
PMID: 16443884
Abstract
To evaluate the impact of prior intensive diabetes therapy on neuropathy among former Diabetes Control and Complications Trial (DCCT) participants. At the conclusion of the DCCT, subjects in the intensive group were encouraged to maintain intensive therapy, and subjects in the conventional group were encouraged to begin intensive therapy. Thereafter, we annually assessed neuropathy as part of the Epidemiology of Diabetes Intervention and Complications (EDIC) study. Neuropathy was defined using the Michigan Neuropathy Screening Instrument (MNSI). We recorded potential adverse consequences of neuropathy. At the first EDIC examination, 1,257 subjects participated in the neuropathy assessment. Consistent with DCCT results, the former intensive group showed a lower prevalence of neuropathy than the conventional group based on positive questionnaire (1.8 vs. 4.7%; P = 0.003) or examination (17.8 vs. 28.0%; P < 0.0001) results. Despite similar levels of glycemic control, symptoms and signs of neuropathy remained less prevalent among the former intensive group compared with the conventional group. At the beginning of the EDIC study, prior intensive therapy reduced the odds of having symptoms and signs of neuropathy using MNSI criteria by 64% (P = 0.0044) and 45% (P < 0.0001), respectively, with similar odds reductions observed for both neuropathic symptoms (51%, P < 0.0001) and neuropathic signs (43%, P < 0.0001) across 8 years of EDIC follow-up. The benefits of 6.5 years of intensive therapy on neuropathy status extended for at least 8 years beyond the end of the DCCT, similar to the findings described for diabetic retinopathy and nephropathy.
Details
- Title: Subtitle
- Neuropathy among the diabetes control and complications trial cohort 8 years after trial completion
- Creators
- Catherine L Martin - Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Intervention and Complications (EDIC) Research Group, Bethesda, MD 20892, USAJames AlbersWilliam H HermanPatricia ClearyBarbara WaberskiDouglas A GreeneMartin J StevensEva L FeldmanDiabetes Control and Complications Trial (DCCT) Research Group
- Contributors
- W Sivitz (Contributor) - University of Iowa, Endocrinology and Metabolism
- Resource Type
- Journal article
- Publication Details
- Diabetes care, Vol.29(2), pp.340-344
- Publisher
- United States
- DOI
- 10.2337/diacare.29.02.06.dc05-1549
- PMID
- 16443884
- PMCID
- PMC2622720
- ISSN
- 0149-5992
- eISSN
- 1935-5548
- Grant note
- N01 DK062204-007 / NIDDK NIH HHS
- Language
- English
- Date published
- 02/2006
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine; Ophthalmology and Visual Sciences
- Record Identifier
- 9983980033502771
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