Journal article
Neuropeptide FF and FMRFamide Potentiate Acid-Evoked Currents from Sensory Neurons and Proton-Gated DEG/ENaC Channels
Neuron (Cambridge, Mass.), Vol.26(1), pp.133-141
04/2000
DOI: 10.1016/S0896-6273(00)81144-7
PMID: 10798398
Abstract
Acidosis is associated with inflammation and ischemia and activates cation channels in sensory neurons. Inflammation also induces expression of FMRFamidelike neuropeptides, which modulate pain. We found that neuropeptide FF (Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe amide) and FMRFamide (Phe-Met-Arg-Phe amide) generated no current on their own but potentiated H+-gated currents from cultured sensory neurons and heterologously expressed ASIC and DRASIC channels. The neuropeptides slowed inactivation and induced sustained currents during acidification. The effects were specific; different channels showed distinct responses to the various peptides. These results suggest that acid-sensing ion channels may integrate multiple extracellular signals to modify sensory perception.
Details
- Title: Subtitle
- Neuropeptide FF and FMRFamide Potentiate Acid-Evoked Currents from Sensory Neurons and Proton-Gated DEG/ENaC Channels
- Creators
- Candice C AskwithChun ChengMutsuhiro IkumaChristopher BensonMargaret P PriceMichael J Welsh
- Resource Type
- Journal article
- Publication Details
- Neuron (Cambridge, Mass.), Vol.26(1), pp.133-141
- DOI
- 10.1016/S0896-6273(00)81144-7
- PMID
- 10798398
- ISSN
- 0896-6273
- eISSN
- 1097-4199
- Language
- English
- Date published
- 04/2000
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Pulmonary, Critical Care, and Occupational Medicine; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Neurosurgery; Internal Medicine
- Record Identifier
- 9984020732502771
Metrics
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