Journal article
Neuropeptide regulation of signaling and behavior in the BNST
Molecules and cells, Vol.38(1), pp.1-13
01/31/2015
DOI: 10.14348/molcells.2015.2261
PMCID: PMC4314126
PMID: 25475545
Abstract
Recent technical developments have transformed how neuroscientists can probe brain function. What was once thought to be difficult and perhaps impossible, stimulating a single set of long range inputs among many, is now relatively straight-forward using optogenetic approaches. This has provided an avalanche of data demonstrating causal roles for circuits in a variety of behaviors. However, despite the critical role that neuropeptide signaling plays in the regulation of behavior and physiology of the brain, there have been remarkably few studies demonstrating how peptide release is causally linked to behaviors. This is likely due to both the different time scale by which peptides act on and the modulatory nature of their actions. For example, while glutamate release can effectively transmit information between synapses in milliseconds, peptide release is potentially slower [See the excellent review by Van Den Pol on the time scales and mechanisms of release (van den Pol, 2012)] and it can only tune the existing signals via modulation. And while there have been some studies exploring mechanisms of release, it is still not as clearly known what is required for efficient peptide release. Furthermore, this analysis could be complicated by the fact that there are multiple peptides released, some of which may act in contrast. Despite these limitations, there are a number of groups making progress in this area. The goal of this review is to explore the role of peptide signaling in one specific structure, the bed nucleus of the stria terminalis, that has proven to be a fertile ground for peptide action.
Details
- Title: Subtitle
- Neuropeptide regulation of signaling and behavior in the BNST
- Creators
- Thomas L Kash - Bowles Center for Alcohol Studies and Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, USAKristen E Pleil - Bowles Center for Alcohol Studies and Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, USACatherine A Marcinkiewcz - Bowles Center for Alcohol Studies and Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, USAEmily G Lowery-Gionta - Bowles Center for Alcohol Studies and Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, USANicole Crowley - Bowles Center for Alcohol Studies and Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, USAChristopher Mazzone - Bowles Center for Alcohol Studies and Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, USAJonathan Sugam - Bowles Center for Alcohol Studies and Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, USAJ Andrew Hardaway - Bowles Center for Alcohol Studies and Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, USAZoe A McElligott - Bowles Center for Alcohol Studies and Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, USA
- Resource Type
- Journal article
- Publication Details
- Molecules and cells, Vol.38(1), pp.1-13
- Publisher
- Korea (South)
- DOI
- 10.14348/molcells.2015.2261
- PMID
- 25475545
- PMCID
- PMC4314126
- ISSN
- 1016-8478
- eISSN
- 0219-1032
- Grant note
- AA022549 / NIAAA NIH HHS AA019454 / NIAAA NIH HHS AA021319 / NIAAA NIH HHS AA021043 / NIAAA NIH HHS U01 AA020911 / NIAAA NIH HHS AA020911 / NIAAA NIH HHS F32 AA021319 / NIAAA NIH HHS F31 AA022280 / NIAAA NIH HHS F32 AA022549 / NIAAA NIH HHS T32 MH076694 / NIMH NIH HHS F32 AA021043 / NIAAA NIH HHS R01 AA019454 / NIAAA NIH HHS AA022280 / NIAAA NIH HHS AA011605 / NIAAA NIH HHS P50 AA011605 / NIAAA NIH HHS P60 AA011605 / NIAAA NIH HHS
- Language
- English
- Date published
- 01/31/2015
- Academic Unit
- Iowa Neuroscience Institute; Neuroscience and Pharmacology
- Record Identifier
- 9984040351602771
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