Journal article
Neurophysiological Correlates and Differential Drug Response in Subjects With a Family History of an Alcohol Use Disorder
Chronic stress (Thousand Oaks, Calif.), Vol.3, p.247054701986526
2019
DOI: 10.1177/2470547019865267
PMCID: PMC6738944
PMID: 31511840
Abstract
A family history of an alcohol use disorder (AUD) has been shown to increase one’s risk of developing an AUD. Additionally, a positive family history of AUD (family history positive (FHP)) has neurobiological and neuropsychopharmacological consequences, and this review summarizes differential drug response as well as neuroanatomical and neurocognitive correlates. FHP status is related to altered responses to a number of drugs, including substances with abuse liability like alcohol, opioids, amphetamines, and ketamine. FHP individuals demonstrate fewer aversive effects and more rewarding response to both alcohol and subanesthetic dose ketamine. Ketamine is a rapid-acting antidepressant, and several studies have reported that ketamine is more effective for FHP treatment-resistant depressed individuals. In short, the reviewed neurophysiological differences may contribute to ketamine’s enhanced antidepressant efficacy in FHP patients. Volumetric differences in the amygdala, nucleus accumbens, neocortex, and cerebellum are commonly reported. Furthermore, FHP has also been associated with altered neurocognitive performance, e.g., increased impulsivity. The imaging and psychological literature supports a neurodevelopmental lag hypothesis in FHP youth. The review will further discuss these findings in depth.
Details
- Title: Subtitle
- Neurophysiological Correlates and Differential Drug Response in Subjects With a Family History of an Alcohol Use Disorder
- Creators
- Sage M Comstock - Department of Psychiatry, Iowa Neuroscience Institute, University of Iowa Health Care, Iowa City, IA, USAJatin G Vaidya - Department of Psychiatry, Iowa Neuroscience Institute, University of Iowa Health Care, Iowa City, IA, USAMark J Niciu - Department of Psychiatry, Iowa Neuroscience Institute, University of Iowa Health Care, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Chronic stress (Thousand Oaks, Calif.), Vol.3, p.247054701986526
- DOI
- 10.1177/2470547019865267
- PMID
- 31511840
- PMCID
- PMC6738944
- ISSN
- 2470-5470
- eISSN
- 2470-5470
- Grant note
- DOI: 10.13039/100000027, name: National Institute on Alcohol Abuse and Alcoholism, award: R00 AA024142
- Language
- English
- Date published
- 2019
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute; University College Courses
- Record Identifier
- 9984071794502771
Metrics
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