Journal article
Neuropilin-1 Conveys Semaphorin and VEGF Signaling during Neural and Cardiovascular Development
Developmental cell, Vol.5(1), pp.45-57
2003
DOI: 10.1016/S1534-5807(03)00169-2
PMCID: PMC3918747
PMID: 12852851
Abstract
Neuropilin-1 (Npn-1) is a receptor that binds multiple ligands from structurally distinct families, including secreted semaphorins (Sema) and vascular endothelial growth factors (VEGF). We generated
npn-1 knockin mice, which express an altered ligand binding site variant of Npn-1, and
npn-1 conditional null mice to establish the cell-type- and ligand specificity of Npn-1 function in the developing cardiovascular and nervous systems. Our results show that VEGF-Npn-1 signaling in endothelial cells is required for angiogenesis. In striking contrast, Sema-Npn-1 signaling is not essential for general vascular development but is required for axonal pathfinding by several populations of neurons in the CNS and PNS. Remarkably, both Sema-Npn-1 signaling and VEGF-Npn-1 signaling are critical for heart development. Therefore, Npn-1 is a multifunctional receptor that mediates the activities of structurally distinct ligands during development of the heart, vasculature, and nervous system.
Details
- Title: Subtitle
- Neuropilin-1 Conveys Semaphorin and VEGF Signaling during Neural and Cardiovascular Development
- Creators
- Chenghua Gu - Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 USAE.Rene Rodriguez - Department of Pathology, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 USADorothy V Reimert - Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 USATianzhi Shu - Department of Anatomy and Neurobiology, School of Medicine, The University of Maryland, Baltimore, Baltimore, MD 21201 USABernd Fritzsch - Department of Biomedical Sciences, Creighton University, Omaha, NE 68178 USALinda J Richards - Department of Anatomy and Neurobiology, School of Medicine, The University of Maryland, Baltimore, Baltimore, MD 21201 USAAlex L Kolodkin - Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 USADavid D Ginty - Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 USA
- Resource Type
- Journal article
- Publication Details
- Developmental cell, Vol.5(1), pp.45-57
- DOI
- 10.1016/S1534-5807(03)00169-2
- PMID
- 12852851
- PMCID
- PMC3918747
- NLM abbreviation
- Dev Cell
- ISSN
- 1534-5807
- eISSN
- 1878-1551
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2003
- Academic Unit
- Iowa Neuroscience Institute; Biology; Craniofacial Anomalies Research Center
- Record Identifier
- 9984070731702771
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