Neuropsychiatric outcomes following strokes involving the cerebellum: a retrospective cohort study

Victoria Muller Ewald; Carolina Deifelt Streese; Joel Bruss; Kenneth Manzel; Lilian Montilla; Ilisa Gala; Daniel Tranel; Krystal Parker

doi:10.3389/fnins.2023.1203488

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Neuropsychiatric outcomes following strokes involving the cerebellum: a retrospective cohort study

Journal article

Open access

Peer reviewed

Neuropsychiatric outcomes following strokes involving the cerebellum: a retrospective cohort study

Victoria Muller Ewald, Carolina Deifelt Streese, Joel Bruss, Kenneth Manzel, Lilian Montilla, Ilisa Gala, Daniel Tranel and Krystal Parker

Frontiers in neuroscience, Vol.17, 1203488

07/03/2023

DOI: 10.3389/fnins.2023.1203488

PMCID: PMC10352988

PMID: 37469842

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Abstract

Given the wide-ranging involvement of cerebellar activity in motor, cognitive, and affective functions, clinical outcomes resulting from cerebellar damage can be hard to predict. Cerebellar vascular accidents are rare, comprising less than 5% of strokes, yet this rare patient population could provide essential information to guide our understanding of cerebellar function. To gain insight into which domains are affected following cerebellar damage, we retrospectively examined neuropsychiatric performance following cerebellar vascular accidents in cases registered on a database of patients with focal brain injuries. Neuropsychiatric testing included assessment of cognitive (working memory, language processing and, perceptual reasoning), motor (eye movements and fine motor control), and affective (depression and anxiety) domains. Results indicate that cerebellar vascular accidents are more common in men and starting in the 5th decade of life, in agreement with previous reports. Additionally, in our group of twenty-six patients, statistically significant performance alterations were not detected at the group level an average of 1.3 years following the vascular accident. Marginal decreases in performance were detected in the word and color sub-scales of the Stroop task, the Rey Auditory Verbal Learning Test, and the Lafayette Grooved Pegboard Test. It is well established that the acute phase of cerebellar vascular accidents can be life-threatening, largely due to brainstem compression. In the chronic phase, our findings indicate that recovery of cognitive, emotional, and affective function is likely. However, a minority of individuals may suffer significant long-term performance impairments in motor coordination, verbal working memory and/or linguistic processing.

Accidents

Ataxia

Brain Injury

Cerebellum

Hypertension

Magnetic Resonance Imaging

Stroke

Auditory discrimination learning

Brain stem

Cognitive ability

Compression

Dysarthria

Information processing

Language

Memory

Motor task performance

Patients

Short term memory

Statistical analysis

Veins & arteries

Details

Title: Subtitle: Neuropsychiatric outcomes following strokes involving the cerebellum: a retrospective cohort study
Creators: Victoria Muller Ewald
Carolina Deifelt Streese
Joel Bruss - University of Iowa
Kenneth Manzel - University of Iowa
Lilian Montilla - University of Iowa
Ilisa Gala - University of Iowa
Daniel Tranel - University of Iowa
Krystal Parker - University of Iowa
Resource Type: Journal article
Publication Details: Frontiers in neuroscience, Vol.17, 1203488
DOI: 10.3389/fnins.2023.1203488
PMID: 37469842
PMCID: PMC10352988
NLM abbreviation: Front Neurosci
ISSN: 1662-4548
eISSN: 1662-453X
Publisher: Frontiers Research Foundation
Grant note: DOI: 10.13039/100000002, name: National Institutes of Health, award: P50 MH094258
Language: English
Date published: 07/03/2023
Academic Unit: Neurology; Psychiatry; Stead Family Department of Pediatrics; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neurosurgery
Record Identifier: 9984442225202771

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