Neuropsychological assessments in a large cohort of pediatric palliative epilepsy surgery patients

M. Jeno; J. Koop; M. Gabriel; A. Caraway; E. Novotny; K. Patrick; E. Gonzalez-Giraldo; K. Auguste; A. Ostendorf; K. McNally; A. Alexander; G. Berrios-Servios; K. Eschbach; J. Bolton; A. Ailion; R. Singh; L. Wong-Kisiel; M. Zaccariello; P. Tatachar; P. Duong; D. Depositario-Cabacar; M. Berl; L. Sepeta; C. Karakas; S. Karia; L. Mohapatra; E. Rowmanowski; N. McNamara; E. Hodges; D. Shrey; H. Hennrick; J. Olaya; K. Arredondo; R. DeLeon; S. Reddy; A. Molnar; P. Javarayee; S E Park; J. Coryell; E. Olsen; D J Bearden; M. Winston; D. Samanta; D. Armstrong; S. Wolf; P. McGoldrick; A. Marashly; Z. Grinspan; S. Nangia; M. Perry; M. Ciliberto

doi:10.1016/j.yebeh.2026.110943

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Neuropsychological assessments in a large cohort of pediatric palliative epilepsy surgery patients

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Neuropsychological assessments in a large cohort of pediatric palliative epilepsy surgery patients

M. Jeno, J. Koop, M. Gabriel, A. Caraway, E. Novotny, K. Patrick, E. Gonzalez-Giraldo, K. Auguste, A. Ostendorf, K. McNally, …

Epilepsy & behavior, Vol.178, 110943

05/2026

DOI: 10.1016/j.yebeh.2026.110943

PMID: 41762947

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Abstract

Background Pediatric patients with drug-resistant epilepsy (DRE) are often referred for evaluation to consider epilepsy surgery. Neuropsychological testing is recommended for all patients undergoing surgical evaluation. Prevalence and factors affecting testing of neuropsychological testing in palliative epilepsy surgery are unknown. Methods Data was collected from the PERC surgical database, a collaboration of pediatric epilepsy centers prospectively enrolling pediatric patients undergoing epilepsy surgery evaluation. Pediatric patients with DRE who sought care at PERC centers, underwent first-time palliative epilepsy surgery, and had neurocognitive data collected were included. Results 569 patients had complete data with some form of neuropsychological assessment documented. Patients with focal motor (0.42 [CI 95% 0.28, 0.62] < 0.01) or cognitive delays (0.20 [CI 95% 0.13, 0.31] < 0.01) were less likely to receive neuropsychological testing, as were those with genetic etiology (0.5x, [CI 95% 0.33, 0.75] p < 0.01). The number of domains evaluated within corpus callosotomy (CC) (median 3, (1-9) < 0.01) and hemispherectomy (median 4 (1-9) < 0.01) groups was significantly lower than testing in other surgical groups. In addition the cognitive IQ and adaptive IQ were lower in patients undergoing CC and compared to other groups. Conclusions All types of patients undergoing palliative epilepsy surgery had some neuropsychological testing. However, those with lower IQ and those undergoing CC or hemispherectomy were less likely to undergo testing. Reduced rates of testing in certain groups indicates room for improvement, especially given recommendations to use testing to help determine surgical success.

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Title: Subtitle: Neuropsychological assessments in a large cohort of pediatric palliative epilepsy surgery patients
Creators: M. Jeno - University of California, San Francisco
J. Koop - Medical College of Wisconsin
M. Gabriel - Cook Children's Medical Center
A. Caraway - Cook Children's Medical Center
E. Novotny - University of Washington
K. Patrick - Seattle Children's Hospital
E. Gonzalez-Giraldo - University of California, San Francisco
K. Auguste - University of California, San Francisco
A. Ostendorf - Nationwide Children's Hospital
K. McNally - Nationwide Children's Hospital
A. Alexander - Children's Hospital Colorado
G. Berrios-Servios - Children's Hospital Colorado
K. Eschbach - Children's Hospital Colorado
J. Bolton - Boston Children's Hospital
A. Ailion - Boston Children's Hospital
R. Singh - Levine Children's Hospital
L. Wong-Kisiel - Mayo Clinic in Arizona
M. Zaccariello - Mayo Clinic in Arizona
P. Tatachar - Lurie Children's Hospital
P. Duong - Northwestern University
D. Depositario-Cabacar - Children's National
M. Berl - Children's National
L. Sepeta - Children's National
C. Karakas - Children's National
S. Karia - University of Louisville
L. Mohapatra - University of Louisville
E. Rowmanowski - University of Michigan
N. McNamara - University of Michigan
E. Hodges - University of Michigan
D. Shrey - Children's Hospital of Orange County
H. Hennrick - Children's Hospital of Orange County
J. Olaya - Children's Hospital of Orange County
K. Arredondo - The University of Texas at Austin
R. DeLeon - The University of Texas at Austin
S. Reddy - Vanderbilt University
A. Molnar - Vanderbilt University
P. Javarayee - Medical College of Wisconsin
S E Park - Medical College of Wisconsin
J. Coryell - Oregon Health & Science University
E. Olsen - Oregon Health & Science University
D J Bearden - Children's Healthcare of Atlanta
M. Winston - Emory University
D. Samanta - University of Arkansas for Medical Sciences
D. Armstrong - Southwestern Medical Center
S. Wolf - Boston Children's Health Physicians
P. McGoldrick - Boston Children's Health Physicians
A. Marashly - Johns Hopkins University
Z. Grinspan - Cornell University
S. Nangia - Cornell University
M. Perry - Cook Children's Medical Center
M. Ciliberto - University of Iowa
Resource Type: Journal article
Publication Details: Epilepsy & behavior, Vol.178, 110943
DOI: 10.1016/j.yebeh.2026.110943
PMID: 41762947
NLM abbreviation: Epilepsy Behav
ISSN: 1525-5050
eISSN: 1525-5069
Publisher: Elsevier Inc
Language: English
Electronic publication date: 02/27/2026
Date published: 05/2026
Academic Unit: Neurology; Stead Family Department of Pediatrics; Neurology (Pediatrics)
Record Identifier: 9985141899502771

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