Journal article
Neuropsychological evidence of multi-domain network hubs in the human thalamus
eLife, Vol.10, e69480
10/08/2021
DOI: 10.7554/eLife.69480
PMCID: PMC8526062
PMID: 34622776
Abstract
Hubs in the human brain support behaviors that arise from brain network interactions. Previous studies have identified hub regions in the human thalamus that are connected with multiple functional networks. However, the behavioral significance of thalamic hubs has yet to be established. Our framework predicts that thalamic subregions with strong hub properties are broadly involved in functions across multiple cognitive domains. To test this prediction, we studied human patients with focal thalamic lesions in conjunction with network analyses of the human thalamocortical functional connectome. In support of our prediction, lesions to thalamic subregions with stronger hub properties were associated with widespread deficits in executive, language, and memory functions, whereas lesions to thalamic subregions with weaker hub properties were associated with more limited deficits. These results highlight how a large-scale network model can broaden our understanding of thalamic function for human cognition.
Details
- Title: Subtitle
- Neuropsychological evidence of multi-domain network hubs in the human thalamus
- Creators
- Kai Hwang - University of Iowa, Iowa Neuroscience InstituteJames M. Shine - University of IowaJoel Bruss - University of Iowa, Stead Family Department of PediatricsDaniel Tranel - University of Iowa, Iowa Neuroscience InstituteAaron Boes - University of Iowa, Neurology (Pediatrics)
- Resource Type
- Journal article
- Publication Details
- eLife, Vol.10, e69480
- DOI
- 10.7554/eLife.69480
- PMID
- 34622776
- PMCID
- PMC8526062
- NLM abbreviation
- Elife
- ISSN
- 2050-084X
- eISSN
- 2050-084X
- Publisher
- eLIFE SCIENCES PUBL LTD
- Number of pages
- 24
- Grant note
- GNT1156536 / National Health and Medical Research Council; National Health and Medical Research Council (NHMRC) of Australia Neuroscience Research Foundation R01MH122613; RO1MH117772; P50MH094258; R01NS114405; R21MH120441 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 10/08/2021
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Psychiatry; Stead Family Department of Pediatrics; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neurology (Pediatrics)
- Record Identifier
- 9984528117802771
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