Neuropsychological performance in first-episode adolescents with schizophrenia: a comparison with first-episode adults and adolescent control subjects

Tonya White; Beng-Choon Ho; Julianna Ward; Daniel O'Leary; Nancy C Andreasen

doi:10.1016/j.biopsych.2006.01.002

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Neuropsychological performance in first-episode adolescents with schizophrenia: a comparison with first-episode adults and adolescent control subjects

Journal article

Peer reviewed

Neuropsychological performance in first-episode adolescents with schizophrenia: a comparison with first-episode adults and adolescent control subjects

Tonya White, Beng-Choon Ho, Julianna Ward, Daniel O'Leary and Nancy C Andreasen

Biological psychiatry (1969), Vol.60(5), pp.463-471

09/01/2006

DOI: 10.1016/j.biopsych.2006.01.002

PMID: 16566898

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Abstract

The goal of this study was to compare the extent of cognitive deficits between adolescents and adults early in the course of schizophrenia. A comprehensive neuropsychological battery was performed on 49 adolescents with childhood- or adolescent-onset schizophrenia, 139 adults with adult-onset schizophrenia, 32 healthy adolescent volunteers, and 240 healthy adult volunteers. Both patient groups were assessed early in the course of their illness and were matched to their respective control groups on age and parental education. The adolescent patients performed significantly worse than the adult patients on tasks of working memory, language, and motor function. The healthy adolescents also performed significantly worse than the healthy adults in working memory and language tasks but were significantly better than the adults in motor function. When accounting for developmental differences in the control group, only motor performance was worse in the adolescent patients compared with the adult patients. These findings, when coupled with published retrospective studies reporting greater cognitive deficits in earlier onset schizophrenia, implicate a cessation in development in specific cognitive domains following the onset of schizophrenia in adolescent patients.

Verbal Behavior - physiology

Humans

Male

Reference Values

Schizophrenia - complications

Memory, Short-Term - physiology

Adolescent Development - physiology

Brain - growth & development

Schizophrenic Psychology

Case-Control Studies

Psychiatric Status Rating Scales

Schizophrenia - diagnosis

Cognition Disorders - etiology

Matched-Pair Analysis

Psychology, Adolescent

Statistics, Nonparametric

Adult

Female

Motor Skills - physiology

Aging - psychology

Problem Solving - physiology

Neuropsychological Tests

Cognition Disorders - diagnosis

Cognition Disorders - complications

Aging - physiology

Adolescent

Age of Onset

Longitudinal Studies

Details

Title: Subtitle: Neuropsychological performance in first-episode adolescents with schizophrenia: a comparison with first-episode adults and adolescent control subjects
Creators: Tonya White - Division of Child and Adolescent Psychiatry, Center for Neurobehavioral Development, University of Minnesota School of Medicine, Minneapolis, MN 55454, USA. twhite@umn.edu
Beng-Choon Ho
Julianna Ward
Daniel O'Leary
Nancy C Andreasen
Resource Type: Journal article
Publication Details: Biological psychiatry (1969), Vol.60(5), pp.463-471
Publisher: United States
DOI: 10.1016/j.biopsych.2006.01.002
PMID: 16566898
ISSN: 0006-3223
eISSN: 1873-2402
Grant note: MH068540 / NIMH NIH HHS MH31593 / NIMH NIH HHS MH40856 / NIMH NIH HHS MH43271 / NIMH NIH HHS
Language: English
Date published: 09/01/2006
Academic Unit: Psychiatry; Iowa Neuroscience Institute
Record Identifier: 9984003404702771

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