Neuropsychological profile in adult schizophrenia measured with the CMINDS

Theo G.M van Erp; Adrian Preda; Jessica A Turner; Shawn Callahan; Vince D Calhoun; Juan R Bustillo; Kelvin O Lim; Bryon Mueller; Gregory G Brown; Jatin G Vaidya; Sarah McEwen; Aysenil Belger; James Voyvodic; Daniel H Mathalon; Dana Nguyen; Judith M Ford; Steven G Potkin

doi:10.1016/j.psychres.2015.10.028

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Neuropsychological profile in adult schizophrenia measured with the CMINDS

Theo G.M van Erp, Adrian Preda, Jessica A Turner, Shawn Callahan, Vince D Calhoun, Juan R Bustillo, Kelvin O Lim, Bryon Mueller, Gregory G Brown, Jatin G Vaidya, …

Psychiatry research, Vol.230(3), pp.826-834

12/30/2015

DOI: 10.1016/j.psychres.2015.10.028

PMCID: PMC4692593

PMID: 26586142

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Abstract

Schizophrenia neurocognitive domain profiles are predominantly based on paper-and-pencil batteries. This study presents the first schizophrenia domain profile based on the Computerized Multiphasic Interactive Neurocognitive System (CMINDS®). Neurocognitive domain z-scores were computed from computerized neuropsychological tests, similar to those in the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery (MCCB), administered to 175 patients with schizophrenia and 169 demographically similar healthy volunteers. The schizophrenia domain profile order by effect size was Speed of Processing (d=−1.14), Attention/Vigilance (d=−1.04), Working Memory (d=−1.03), Verbal Learning (d=−1.02), Visual Learning (d=−0.91), and Reasoning/Problem Solving (d=−0.67). There were no significant group by sex interactions, but overall women, compared to men, showed advantages on Attention/Vigilance, Verbal Learning, and Visual Learning compared to Reasoning/Problem Solving on which men showed an advantage over women. The CMINDS can readily be employed in the assessment of cognitive deficits in neuropsychiatric disorders; particularly in large-scale studies that may benefit most from electronic data capture.\n•This study presents the first CMINDS® battery schizophrenia cognitive domain profile.•The schizophrenia profile shows the strongest effect size for speed of processing.•Women perform better than men on attention, speed of processing, and verbal learning.•Men perform better than women on reasoning.•Computerized neuropsychological batteries can be used in neuropsychiatric studies.

Psychosis

MCCB

Memory

MATRICS

Sex

Neuropsychology

Speed of processing

Details

Title: Subtitle: Neuropsychological profile in adult schizophrenia measured with the CMINDS
Creators: Theo G.M van Erp - Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA 92617, USA
Adrian Preda - Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA 92617, USA
Jessica A Turner - Departments of Psychology and Neuroscience, Georgia State University, Atlanta, GA 30303, USA
Shawn Callahan - Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA 92617, USA
Vince D Calhoun - Mind Research Network, Albuquerque, NM 87106, USA
Juan R Bustillo - Departments of Psychiatry & Neuroscience, University of New Mexico, Albuquerque, NM 87131, USA
Kelvin O Lim - Department of Psychiatry, University of Minnesota, Minneapolis, MN 55454, USA
Bryon Mueller - Department of Psychiatry, University of Minnesota, Minneapolis, MN 55454, USA
Gregory G Brown - VA San Diego Healthcare System and Department of Psychiatry, University of California San Diego, CA 92161, USA
Jatin G Vaidya - Department of Psychiatry, University of Iowa, Iowa City, IA 52242, USA
Sarah McEwen - Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095, USA
Aysenil Belger - Departments of Psychiatry and Psychology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
James Voyvodic - Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC 27710, USA
Daniel H Mathalon - Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94143, USA
Dana Nguyen - Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA 92617, USA
Judith M Ford - Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94143, USA
Steven G Potkin - Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA 92617, USA
Resource Type: Journal article
Publication Details: Psychiatry research, Vol.230(3), pp.826-834
DOI: 10.1016/j.psychres.2015.10.028
PMID: 26586142
PMCID: PMC4692593
NLM abbreviation: Psychiatry Res
ISSN: 0165-1781
eISSN: 1872-7123
Publisher: Elsevier Ireland Ltd
Grant note: DOI: 10.13039/100000002, name: National Institutes of Health, award: 1 U24 RR025736-01, NIH 1 U24 RR021992; DOI: 10.13039/100000097, name: National Center for Research Resources
Language: English
Date published: 12/30/2015
Academic Unit: Psychiatry; Iowa Neuroscience Institute; University College Courses
Record Identifier: 9984070331402771

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