Neuroticism but not omega-3 fatty acid levels correlate with early responsiveness to escitalopram

Jess G Fiedorowicz; Nancy Hale; Arthur A Spector; William H Coryell

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Neuroticism but not omega-3 fatty acid levels correlate with early responsiveness to escitalopram

Journal article

Peer reviewed

Neuroticism but not omega-3 fatty acid levels correlate with early responsiveness to escitalopram

Jess G Fiedorowicz, Nancy Hale, Arthur A Spector and William H Coryell

Annals of clinical psychiatry, Vol.22(3), pp.157-163

08/2010

PMCID: PMC3035677

PMID: 20680188

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Abstract

Omega-3 fatty acid (O3FA) levels and dimensional personality measures have been associated with major depression and the course of depressive illness. We sought to study the utility of O3FA levels and dimensional personality measures as predictors of early improvement with escitalopram. Twenty-four participants were enrolled in an open-label trial of escitalopram 10 mg/d for 4 weeks. Baseline erythrocyte O3 levels and dimensional personality assessments were obtained. Using a conservative, intention-to-treat analysis, baseline neuroticism (r = -0.57; P = .007), as measured by the Revised NEO Personality Inventory but not erythrocyte O3 levels, was correlated with improvements on escitalopram. A facet analysis of the neuroticism domain showed the relationship with antidepressant response to be focused on trait anxiety (r = -0.65; P = .002). Anxiety may have important prognostic implications on subsequent response to selective serotonin reuptake inhibitors, such as escitalopram.

Depressive Disorder, Major - blood

Antidepressive Agents, Second-Generation - adverse effects

Prognosis

Prospective Studies

Humans

Middle Aged

Citalopram - adverse effects

Male

Neurotic Disorders - blood

Antidepressive Agents, Second-Generation - therapeutic use

Adult

Female

Anxiety Disorders - drug therapy

Personality Inventory - statistics & numerical data

Depressive Disorder, Major - drug therapy

Anxiety Disorders - blood

Character

Neurotic Disorders - drug therapy

Psychometrics

Treatment Outcome

Anxiety Disorders - psychology

Neurotic Disorders - psychology

Depressive Disorder, Major - psychology

Erythrocytes - metabolism

Citalopram - therapeutic use

Fatty Acids, Omega-3 - blood

Details

Title: Subtitle: Neuroticism but not omega-3 fatty acid levels correlate with early responsiveness to escitalopram
Creators: Jess G Fiedorowicz - Departments of Psychiatry and Epidemiology, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA. jess-fiedorowicz@uiowa.edu
Nancy Hale
Arthur A Spector
William H Coryell
Resource Type: Journal article
Publication Details: Annals of clinical psychiatry, Vol.22(3), pp.157-163
Publisher: United States
PMID: 20680188
PMCID: PMC3035677
ISSN: 1040-1237
eISSN: 1547-3325
Grant note: UL1 RR024979 / NCRR NIH HHS L30 MH075180 / NIMH NIH HHS 3 UL1 RR024979-03S4 / NCRR NIH HHS 1K23MH083695-01A210 / NIMH NIH HHS K23 MH083695 / NIMH NIH HHS KL2 RR024980 / NCRR NIH HHS L30 MH075180-01 / NIMH NIH HHS
Language: English
Date published: 08/2010
Academic Unit: Psychiatry; Epidemiology; Biochemistry and Molecular Biology; Internal Medicine
Record Identifier: 9984004099302771

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