Journal article
Neurotoxicity of FOLFOX-4 as adjuvant treatment for patients with colon and gastric cancer: A randomized study of two different schedules of oxaliplatin
Cancer chemotherapy and pharmacology, Vol.61(1), pp.105-111
2008
DOI: 10.1007/s00280-007-0454-3
PMID: 17429632
Abstract
Purpose
The dose limiting toxicity of oxaliplatin (l-HOP) is neurotoxicity, which is characterized by an acute neuropathy and a clinically distinct chronic neuropathy. This randomized study evaluated if prolonged l-HOP infusion over the conventional l-HOP schedule was useful in reducing acute and possibly chronic l-HOP induced neurotoxicity in colon and gastric cancer patients receiving l-HOP-based regimen as adjuvant chemotherapy.
Methods
Sixty-four patients were randomly assigned to group A (26 colon and 6 gastric cancer) and to group B (23 colon and 9 gastric cancer). Chemotherapy in both groups consisted of l-HOP 85 mg/m2 i.v. only on day 1, with leucovorin 100 mg/m2 i.v. as a 2-h infusion followed by bolus 5-fluorouracil (5-FU) 400 mg/m2/day and a 22-h infusion of 5-FU 600 mg/m2/day, repeated for two consecutive days every 2 weeks for a maximum of 12 cycles. Patients in group A received l-HOP as a continuous 6-h i.v. infusion, and patients in group B received l-HOP as the conventional 2-h i.v. infusion.
Results
The percentage of patients presenting with grade ≥2 neurotoxicity was statistically lower in group A than in group B (28.1% vs. 59.3%: P = 0.02). There was a statistically lower percentage of cycles with grade ≥2 neurotoxicity in group A (6.1%) than in group B (18.5%) (P < 0.001).
Conclusions
This study suggests that l-HOP as a continuous 6-h infusion is useful in preventing and reducing acute l-HOP induced neurotoxicity in patients with colon and gastric cancer receiving FOLFOX-4 regimen as adjuvant treatment.
Details
- Title: Subtitle
- Neurotoxicity of FOLFOX-4 as adjuvant treatment for patients with colon and gastric cancer: A randomized study of two different schedules of oxaliplatin
- Creators
- Roberto Petrioli - University of SienaAlessandra Pascucci - University of SienaEdoardo Francini - University of SienaStefania Marsili - University of SienaAngela Sciandivasci - University of SienaRossana Tassi - University of SienaSerenella Civitelli - University of SienaGabriello Tanzini - University of SienaMarco Lorenzi - University of SienaGuido Francini - University of Siena
- Resource Type
- Journal article
- Publication Details
- Cancer chemotherapy and pharmacology, Vol.61(1), pp.105-111
- DOI
- 10.1007/s00280-007-0454-3
- PMID
- 17429632
- ISSN
- 0344-5704
- eISSN
- 1432-0843
- Number of pages
- 7
- Language
- English
- Date published
- 2008
- Academic Unit
- Internal Medicine
- Record Identifier
- 9985221143202771
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