Journal article
New Autonomous Water-Enabled Self-Healing Coating Material with Antibacterial-Agent-Releasing Properties
Pharmaceutics, Vol.14(5), p.1005
05/07/2022
DOI: 10.3390/pharmaceutics14051005
PMCID: PMC9143542
PMID: 35631591
Abstract
A new autonomous water-enabled self-healing coating with antibacterial-agent-releasing capability was developed for the first time by precipitating an aqueous solution of hydrogen-bonded tannic acid (TA) and polyethylene glycol (PEG) (TA: 5 mg/mL; PEG: 5 mg/mL with M-W = 100 kDa) to form a smooth, uniform coating layer with an average roughness of 0.688 nm and thickness of 22.3 mu m on a polymethyl methacrylate (PMMA) substrate after 10 min of incubation. Our method is cost- and time-efficient, as the hydrophilic coating (water contact angle = 65.1 degrees) forms rapidly, binding strongly to the PMMA substrate (adhesive energy = 83 mJ/m(2)), without the need for pretreatment or surface modification, and is capable of rapid self-repair (approximately 5 min) through hydrogen bonding in aqueous media. Furthermore, adding 0.5 mg/mL of chlorhexidine acetate (CHX), a commonly used antibacterial agent in dentistry, into the TA-PEG emulsion allowed the release of 2.89 mu g/mL of the drug from the coating layer, which is promising for actively inhibiting the vitality and growth of bacteria around PMMA dental restorations. The use of CHX-loaded TA-PEG hydrogen-bonded complexes is highly favorable for the fabrication of an autonomous self-healing biocoating with active antibacterial-agent-releasing capability, which can be applied not only in dentistry but also in other medical fields.
Details
- Title: Subtitle
- New Autonomous Water-Enabled Self-Healing Coating Material with Antibacterial-Agent-Releasing Properties
- Creators
- Ki-Hak Kim - Kyungpook National UniversityHang-Nga Mai - Kyungpook Natl Univ, Inst Translat Res Dent, Daegu 41940, South KoreaDong-Choon Hyun - Kyungpook National UniversityDu-Hyeong Lee - Kyungpook Natl Univ, Sch Dent, Dept Prosthodont, Daegu 41940, South Korea
- Resource Type
- Journal article
- Publication Details
- Pharmaceutics, Vol.14(5), p.1005
- DOI
- 10.3390/pharmaceutics14051005
- PMID
- 35631591
- PMCID
- PMC9143542
- NLM abbreviation
- Pharmaceutics
- ISSN
- 1999-4923
- eISSN
- 1999-4923
- Publisher
- Mdpi
- Number of pages
- 14
- Grant note
- 2020R1A2C4002518; 2021R1A2C1007129 / National Research Foundation of Korea (NRF) - Korea government (MSIT); National Research Foundation of Korea; Ministry of Science, ICT & Future Planning, Republic of Korea; Ministry of Science & ICT (MSIT), Republic of Korea
- Language
- English
- Date published
- 05/07/2022
- Academic Unit
- Prosthodontics
- Record Identifier
- 9984914144202771
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