Journal article
New Destruxins from the Entomopathogenic Fungus Aschersonia sp
Journal of natural products (Washington, D.C.), Vol.59(5), pp.485-489
05/22/1996
DOI: 10.1021/np9601216
Abstract
Two new insecticidal cyclic depsipeptides, destruxins A4 (1) and A5 (2), were isolated by bioassay-guided fractionation of organic extracts from an undescribed species of entomopathogenic fungus from the genus Aschersonia. Another previously identified but related compound, homodestruxin B (3), was also isolated as a product of this fungus. The chemical structures of 1-3 were determined based on analysis of NMR and mass spectral data. In common with homodestruxin B (3), the novel compounds destruxins A4 (1) and A5 (2) have a Melle moiety in place of the MeVal residue more typically found in destruxins. In addition, destruxin A5 has a β-MePro unit in place of the Pro residue found in most destruxins. LC50 values for 1 and 2 in an insecticidal assay against Drosophila melanogaster were estimated at 41 and 52 ppm, respectively. Homodestruxin B (3) showed no activity at 400 ppm in the same assay. Destruxins A4 (1) and A5 (2) are the first biologically active secondary metabolites reported from the fungal genus Aschersonia, which represents a new source of destruxins.
Details
- Title: Subtitle
- New Destruxins from the Entomopathogenic Fungus Aschersonia sp
- Creators
- Stuart B Krasnoff - USDA-ARS Plant Protection Research Unit, Tower Road, Ithaca, New York 14853Donna M Gibson - USDA-ARS Plant Protection Research Unit, Tower Road, Ithaca, New York 14853Gilbert N Belofsky - USDA-ARS Plant Protection Research Unit, Tower Road, Ithaca, New York 14853Katherine B Gloer - USDA-ARS Plant Protection Research Unit, Tower Road, Ithaca, New York 14853James B Gloer - USDA-ARS Plant Protection Research Unit, Tower Road, Ithaca, New York 14853
- Resource Type
- Journal article
- Publication Details
- Journal of natural products (Washington, D.C.), Vol.59(5), pp.485-489
- Publisher
- American Chemical Society
- DOI
- 10.1021/np9601216
- ISSN
- 0163-3864
- eISSN
- 1520-6025
- Language
- English
- Date published
- 05/22/1996
- Academic Unit
- Chemistry
- Record Identifier
- 9984216686902771
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