Journal article
New Imaging Approaches for Understanding Lung Cancer Response to Treatment
Clinical pharmacology and therapeutics, Vol.84(4), pp.517-522
10/2008
DOI: 10.1038/clpt.2008.160
PMCID: PMC4367487
PMID: 18769370
Abstract
The survival rate for lung cancer patients has barely improved over the past 30 years. New evaluation benchmarks for cancer response are needed to test therapy agents in a cost-effective and timely manner. From recent work, it is evident that primary lung cancers are very complex structures containing not only cancerous cells but also fibrotic and inflammatory cells and necrotic tissue. A greater understanding of the three-dimensional structure of primary lung cancer is emerging, allowing for the first time an appreciation of how this biomass is represented in medical imaging data. It is only through a greater understanding of the lung cancer biomass that we can define rational and early-response measures, including specific cellular responses such as cancer cell death or growth inhibition. In doing so, we can define response metrics that will shorten new drug discovery times and reduce costs, allowing for the evaluation of many more agents with therapeutic potential.
Details
- Title: Subtitle
- New Imaging Approaches for Understanding Lung Cancer Response to Treatment
- Creators
- J de Ryk - Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USAE Namati - Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USAJ Thiesse - Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USAG McLennan - Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- Clinical pharmacology and therapeutics, Vol.84(4), pp.517-522
- DOI
- 10.1038/clpt.2008.160
- PMID
- 18769370
- PMCID
- PMC4367487
- NLM abbreviation
- Clin Pharmacol Ther
- ISSN
- 0009-9236
- eISSN
- 1532-6535
- Language
- English
- Date published
- 10/2008
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology
- Record Identifier
- 9984051557502771
Metrics
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