New Insights into the Immune System Using Dirty Mice

Sara E Hamilton; Vladimir P Badovinac; Lalit K Beura; Mark Pierson; Stephen C Jameson; David Masopust; Thomas S Griffith

doi:10.4049/jimmunol.2000171

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New Insights into the Immune System Using Dirty Mice

Journal article

Peer reviewed

New Insights into the Immune System Using Dirty Mice

Sara E Hamilton, Vladimir P Badovinac, Lalit K Beura, Mark Pierson, Stephen C Jameson, David Masopust and Thomas S Griffith

The Journal of immunology (1950), Vol.205(1), pp.3-11

07/01/2020

DOI: 10.4049/jimmunol.2000171

PMCID: PMC7316151

PMID: 32571979

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Abstract

The mouse ( ) is the dominant organism used to investigate the mechanisms behind complex immunological responses because of their genetic similarity to humans and our ability to manipulate those genetics to understand downstream function. Indeed, our knowledge of immune system development, response to infection, and ways to therapeutically manipulate the immune response to combat disease were, in large part, delineated in the mouse. Despite the power of mouse-based immunology research, the translational efficacy of many new therapies from mouse to human is far from ideal. Recent data have highlighted how the naive, neonate-like immune system of specific pathogen-free mice differs dramatically in composition and function to mice living under barrier-free conditions (i.e., "dirty" mice). In this review, we discuss major findings to date and challenges faced when using dirty mice and specific areas of immunology research that may benefit from using animals with robust and varied microbial exposure.

Animals

Immunity - physiology

Mice - immunology

Mice - microbiology

Microbiota - immunology

Models, Animal

Specific Pathogen-Free Organisms - immunology

Translational Medical Research - methods

Details

Title: Subtitle: New Insights into the Immune System Using Dirty Mice
Creators: Sara E Hamilton - University of Minnesota
Vladimir P Badovinac - University of Iowa
Lalit K Beura - Brown University
Mark Pierson - University of Minnesota
Stephen C Jameson - University of Minnesota
David Masopust - University of Minnesota
Thomas S Griffith - University of Minnesota
Resource Type: Journal article
Publication Details: The Journal of immunology (1950), Vol.205(1), pp.3-11
DOI: 10.4049/jimmunol.2000171
PMID: 32571979
PMCID: PMC7316151
NLM abbreviation: J Immunol
ISSN: 0022-1767
eISSN: 1550-6606
Grant note: I01 BX001324 / BLRD VA R21 AI147064 / NIAID NIH HHS R01 AI084913 / NIAID NIH HHS R01 AI116678 / NIAID NIH HHS R35 GM134880 / NIGMS NIH HHS P30 CA077598 / NCI NIH HHS R01 GM115462 / NIGMS NIH HHS
Language: English
Date published: 07/01/2020
Academic Unit: Microbiology and Immunology; Pathology
Record Identifier: 9984180922402771

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