Journal article
New Insights on the Mechanisms of Myocardial Injury in Hypertensive Patients With COVID-19
Journal of clinical immunology, Vol.43(7), pp.1496-1505
10/01/2023
DOI: 10.1007/s10875-023-01523-6
PMCID: PMC10250847
PMID: 37294518
Abstract
PurposeMyocardial injury is commonin hypertensive patients with 2019 coronavirus disease (COVID-19). Immune dysregulation could be associated to cardiac injury in these patients, but the underlying mechanism has not been fully elucidated.MethodsAll patients were selected prospectively from a multicenter registry of adults hospitalized with confirmed COVID-19. Cases had hypertension and myocardial injury, defined by troponin levels above the 99th percentile upper reference limit, and controls were hypertensive patients with no myocardial injury. Biomarkers and immune cell subsets were quantified and compared between the two groups. A multiple logistic regression model was used to analyze the associations of clinical and immune variables with myocardial injury.ResultsThe sample comprised 193 patients divided into two groups: 47 cases and 146 controls. Relative to controls, cases had lower total lymphocyte count, percentage of T lymphocytes, CD8(+)CD38(+) mean fluorescence intensity (MFI), and percentage of CD8(+) human leukocyte antigen DR isotope (HLA-DR)(+) CD38(-)cells and higher percentage of natural killer lymphocytes, natural killer group 2A (NKG2A)(+) MFI, percentage of CD8(+)CD38(+)cells, CD8(+)HLA-DR+MFI, CD8(+)NKG2A(+)MFI, and percentage of CD8(+)HLA-DR(-)CD38(+)cells. On multivariate regression, the CD8(+)HLA-DR+MFI, CD8(+)CD38(+)MFI, and total lymphocyte count were associated significantly with myocardial injury.ConclusionOur findings suggest that lymphopenia, CD8(+)CD38(+)MFI, and CD8(+)HLA-DR+MFI are immune biomarkers of myocardial injury in hypertensive patients with COVID-19. The immune signature described here may aid in understanding the mechanisms underlying myocardial injury in these patients. The study data might open a new window for improvement in the treatment of hypertensive patients with COVID-19 and myocardial injury.
Details
- Title: Subtitle
- New Insights on the Mechanisms of Myocardial Injury in Hypertensive Patients With COVID-19
- Creators
- Renata Moll-Bernardes - D’Or Institute for Research and EducationJuliana R. Ferreira - D’Or Institute for Research and EducationEduardo B. Schaustz - D’Or Institute for Research and EducationAndrea S. Sousa - DOr Inst Res & Educ, Rua Diniz Cordeiro 30, BR-22281100 Rio De Janeiro, BrazilJoao D. Mattos - D’Or Institute for Research and EducationMariana B. Tortelly - D’Or Institute for Research and EducationAdriana L. Pimentel - D’Or Institute for Research and EducationAna Cristina B. S. Figueiredo - D’Or Institute for Research and EducationMarcia M. Noya-Rabelo - D’Or Institute for Research and EducationSergio Fortier - D’Or Institute for Research and EducationFlavia A. Matos e Silva - D’Or Institute for Research and EducationNarendra Vera - Universidade Federal do Rio de JaneiroLuciana Conde - Universidade Federal do Rio de JaneiroMauro Jorge Cabral-Castro - Universidade Federal FluminenseDenilson C. Albuquerque - DOr Inst Res & Educ, Rua Diniz Cordeiro 30, BR-22281100 Rio De Janeiro, BrazilPaulo Henrique Rosado-de-Castro - D’Or Institute for Research and EducationGabriel C. Camargo - D’Or Institute for Research and EducationMartha V. T. Pinheiro - D’Or Institute for Research and EducationDaniele O. L. Freitas - D’Or Institute for Research and EducationAna M. Pittella - D’Or Institute for Research and EducationJose Afonso M. Araujo - D’Or Institute for Research and EducationAndre C. Marques - D’Or Institute for Research and EducationElias P. Gouvea - D’Or Institute for Research and EducationFlavia V. O. Terzi - D’Or Institute for Research and EducationCleverson N. Zukowski - D’Or Institute for Research and EducationRonaldo A. O. C. Gismondi - D’Or Institute for Research and EducationBruno S. S. Bandeira - D’Or Institute for Research and EducationRenee S. Oliveira - D’Or Institute for Research and EducationBarbara E. J. Abufaiad - D’Or Institute for Research and EducationJacqueline S. Miranda - D’Or Institute for Research and EducationLuiz Guilherme Miranda - D’Or Institute for Research and EducationOlga F. Souza - DOr Inst Res & Educ, Rua Diniz Cordeiro 30, BR-22281100 Rio De Janeiro, BrazilFernando A. Bozza - D’Or Institute for Research and EducationRonir R. Luiz - D’Or Institute for Research and EducationEmiliano Medei - National Institute of Science and Technology for Structural Biology and Bioimaging
- Resource Type
- Journal article
- Publication Details
- Journal of clinical immunology, Vol.43(7), pp.1496-1505
- DOI
- 10.1007/s10875-023-01523-6
- PMID
- 37294518
- PMCID
- PMC10250847
- NLM abbreviation
- J Clin Immunol
- ISSN
- 0271-9142
- eISSN
- 1573-2592
- Publisher
- Springer Nature
- Number of pages
- 10
- Language
- English
- Date published
- 10/01/2023
- Academic Unit
- Radiology
- Record Identifier
- 9985143550402771
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