Journal article
New Means of Canine Leishmaniasis Transmission in North America: The Possibility of Transmission to Humans Still Unknown
Interdisciplinary perspectives on infectious diseases, Vol.2009, pp.1-5
2009
DOI: 10.1155/2009/802712
PMCID: PMC2695953
PMID: 19753139
Abstract
At present it is not possible to determine in advance the outcome of
Leishmania infantum
infection. Canine Visceral Leishmaniasis (VL), caused by
Le. infantum
, is a natural disease process which offers a insight into the interaction of the host and resultant disease outcome. Canine VL results in the same altered pathophysiology and immunodysregulation seen in humans. VL in US dogs is likely to be transmitted primarily via nontraditional, nonvector means. VL mediated by
Le. infantum
is endemic in U.S. Foxhound dogs, with vertical transmission likely to be the novel primary means of transmission. This population of dogs offers an opportunity to identify host factors of natural disease. Prevention of human clinical visceral leishmaniasis can occur only by better understanding the disease ecology of the primary reservoir host: the dog.
Details
- Title: Subtitle
- New Means of Canine Leishmaniasis Transmission in North America: The Possibility of Transmission to Humans Still Unknown
- Creators
- Christine A Petersen - 2764 Veterinary Medicine, Department of Veterinary Pathology, Iowa State University, Ames, IA 50011, USA
- Resource Type
- Journal article
- Publication Details
- Interdisciplinary perspectives on infectious diseases, Vol.2009, pp.1-5
- DOI
- 10.1155/2009/802712
- PMID
- 19753139
- PMCID
- PMC2695953
- NLM abbreviation
- Interdiscip Perspect Infect Dis
- ISSN
- 1687-708X
- eISSN
- 1687-7098
- Publisher
- Hindawi Publishing Corporation
- Grant note
- DOI: 10.13039/100001458, name: American Kennel Club Canine Health Foundation, award: 1159, 1220, NIH R21AI074711
- Language
- English
- Date published
- 2009
- Academic Unit
- Epidemiology; Internal Medicine
- Record Identifier
- 9983995147302771
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