Journal article
New and Efficient Approach to Aryl Phosphoramidate Derivatives of AZT/d4T as Anti-HIV Prodrugs
Synlett, Vol.2004(14), pp.2600-2602
11/11/2004
DOI: 10.1055/s-2004-834800
Abstract
Abstract
Ester exchange of diaryl phosphite with AZT or d4T produced aryl AZT/d4T H-phosphonate, and the following reaction with amino acid esters in the presence of hexachloroethane and triethylamine yielded membrane-soluble anti-HIV prodrugs aryl phosphoramide derivatives of AZT and d4T in good yields.
Details
- Title: Subtitle
- New and Efficient Approach to Aryl Phosphoramidate Derivatives of AZT/d4T as Anti-HIV Prodrugs
- Creators
- Xueshu Li - Tsinghua UniversityHua Fu - Tsinghua UniversityYuyang Jiang - The Key Lab of Chemical Biology, Guangdong Province, College of Shenzhen, Tsinghua University, Shenzhen 518057, P. R. China, fuhua@mail.tsinghua.edu.cnYufen Zhao - The Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, P. R. ChinaJinyong Liu - The Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China
- Resource Type
- Journal article
- Publication Details
- Synlett, Vol.2004(14), pp.2600-2602
- DOI
- 10.1055/s-2004-834800
- ISSN
- 0936-5214
- eISSN
- 1437-2096
- Language
- English
- Date published
- 11/11/2004
- Academic Unit
- Occupational and Environmental Health
- Record Identifier
- 9984303284002771
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