Journal article
New approaches to the treatment of Age-Related Macular Degeneration (AMD)
Experimental eye research, Vol.221, 109134
05/30/2022
DOI: 10.1016/j.exer.2022.109134
Abstract
•Choroid and choriocapillaris are potential important targets of therapy early in AMD.•Macular vasculature pathology, like choriocapillaris flow deficits, can be measured using OCT-A.•Subretinal drusenoid deposits result from biogenesis pathways involved in lipid homeostasis.•How to target (over- or under-express) the HtrA1 gene associated with AMD is controversial.•Optimal gene therapies for AMD depend on retinal delivery site and specificity to retinal cell.
Details
- Title: Subtitle
- New approaches to the treatment of Age-Related Macular Degeneration (AMD)
- Creators
- Karl Csaky - Retina Foundation of the SouthwestChristine A. Curcio - University of Alabama School of MedicineRobert F. Mullins - University of Iowa Hospitals and Clinics, Dept. of Ophthalmology and Visual Sciences, 200 Hawkins Dr., Iowa City, IA, 52242, USAPhilip J. Rosenfeld - University of MiamiJames Fujimoto - Massachusetts Institute of TechnologyBärbel Rohrer - Medical University of South CarolinaRamiro Ribero - Apellis PharmaceuticalsGoldis Malek - Duke UniversityNadia Waheed - Tufts Medical CenterRobyn Guymer - The University of MelbourneGregory S. Hageman - University of UtahHao Chen - GenentechMarie Csete - ConeSight Therapeutics, 2265 E. Foothill Blvd., Pasadena, CA, 91107, USA
- Resource Type
- Journal article
- Publication Details
- Experimental eye research, Vol.221, 109134
- DOI
- 10.1016/j.exer.2022.109134
- ISSN
- 0014-4835
- eISSN
- 1096-0007
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 05/30/2022
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9984263696102771
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