Journal article
New facets of antifungal therapy
Virulence, Vol.8(2), pp.222-236
02/17/2017
DOI: 10.1080/21505594.2016.1257457
PMCID: PMC5354158
PMID: 27820668
Abstract
Invasive fungal infections remain a major cause of morbidity and mortality in immunocompromised patients, and such infections are a substantial burden to healthcare systems around the world. However, the clinically available armamentarium for invasive fungal diseases is limited to 3 main classes (i.e., polyenes, triazoles, and echinocandins), and each has defined limitations related to spectrum of activity, development of resistance, and toxicity. Further, current antifungal therapies are hampered by limited clinical efficacy, high rates of toxicity, and significant variability in pharmacokinetic properties. New antifungal agents, new formulations, and novel combination regimens may improve the care of patients in the future by providing improved strategies to combat challenges associated with currently available antifungal agents. Likewise, therapeutic drug monitoring may be helpful, but its present use remains controversial due to the lack of available data. This article discusses new facets of antifungal therapy with a focus on new antifungal formulations and the synergistic effects between drugs used in combination therapy.
Details
- Title: Subtitle
- New facets of antifungal therapy
- Creators
- Ya-Lin Chang - Department of Plant Pathology and Microbiology, National Taiwan UniversityShang-Jie Yu - Department of Plant Pathology and Microbiology, National Taiwan UniversityJoseph Heitman - Department of Molecular Genetics and Microbiology, Duke UniversityMelanie Wellington - Department of Pediatrics, University of Rochester Medical CenterYing-Lien Chen - Department of Plant Pathology and Microbiology, National Taiwan University
- Resource Type
- Journal article
- Publication Details
- Virulence, Vol.8(2), pp.222-236
- Publisher
- Taylor & Francis
- DOI
- 10.1080/21505594.2016.1257457
- PMID
- 27820668
- PMCID
- PMC5354158
- ISSN
- 2150-5594
- eISSN
- 2150-5608
- Language
- English
- Date published
- 02/17/2017
- Academic Unit
- Stead Family Department of Pediatrics; Infectious Disease (Pediatrics)
- Record Identifier
- 9984093374602771
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