Journal article
New frontiers in prostate cancer imaging: clinical utility of prostate-specific membrane antigen positron emission tomography
International urology and nephrology, Vol.49(5), pp.803-810
05/01/2017
DOI: 10.1007/s11255-017-1541-y
PMID: 28197764
Abstract
Prostate-specific membrane antigen positron emission tomography (PSMA PET) is a relatively new method of imaging prostate cancer that increases diagnostic accuracy in detecting and guiding management in various stages of the disease pathway. Gallium-68-labelled PSMA PET has increased the sensitivity of detection of disease recurrence at low PSA levels, thus allowing an optimal window for salvage treatment. Apart from its use in disease recurrence, PSMA PET has the potential for increasing sensitivity and specificity for primary tumour localisation and in detecting lymph node disease, leading to a more accurate initial staging of the condition. In advanced disease, the use of PSMA PET may be able to assess response to treatment and also guide treatment with radionuclide therapy. Newer ligands under development might provide avenues for theranostic or personalised therapy applications with early data showing high PSA response rates. The rate of translation of PSMA PET into clinical practice has been remarkable. The use of this modality is likely to increase with future efforts to modify the radiotracer including F-18 labelling to improve availability.
Details
- Title: Subtitle
- New frontiers in prostate cancer imaging: clinical utility of prostate-specific membrane antigen positron emission tomography
- Creators
- Asim Afaq - London North West Healthcare NHS TrustDeepak Batura - London North West Healthcare NHS TrustJamshed Bomanji - University College London Hospitals NHS Foundation Trust
- Resource Type
- Journal article
- Publication Details
- International urology and nephrology, Vol.49(5), pp.803-810
- Publisher
- Springer Nature
- DOI
- 10.1007/s11255-017-1541-y
- PMID
- 28197764
- ISSN
- 0301-1623
- eISSN
- 1573-2584
- Number of pages
- 8
- Grant note
- National Institute for Health Research University College London Hospitals Biomedical Research Centre; General Electric London North West Healthcare Charitable Fund Grant
- Language
- English
- Date published
- 05/01/2017
- Academic Unit
- Radiology
- Record Identifier
- 9984318716902771
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